Resmetirom impurity 118 CAS CATO-C4X-2912118
| CAS No. | CATO-C4X-2912118 |
| Molecular Formula | C26H22Cl4N4O4 |
| Molecular Weight | 596.29 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Resmetirom impurity 118 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Resmetirom impurity 118 (CAS CATO-C4X-2912118), a pharmacopoeial impurity reference standard (molecular formula C26H22Cl4N4O4, MW 596.29 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Resmetirom impurity 118 (C26H22Cl4N4O4) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 16.0, corresponding to approximately 16 ring(s) or double-bond equivalent(s). With a molecular weight of 596.29 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Resmetirom impurity 118 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C26H22Cl4N4O4 |
| Molecular Weight | 596.29 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Resmetirom Standards
- Resmetirom impurity 107 (CAS CATO-C4X-2912107)
- Resmetirom impurity 123 (CAS CATO-C4X-2912123)
- Resmetirom impurity 106 (CAS CATO-C4X-2912106)
- Resmetirom impurity 119 (CAS CATO-C4X-2912119)
- Resmetirom Impurity 11 (CAS CATO-C4X-291211)
- Resmetirom impurity 88 (CAS CATO-C4X-291288)
- Resmetirom Impurity 97 (CAS CATO-C4X-291297)
- Resmetirom impurity 115 (CAS CATO-C4X-2912115)
Recommended Standards
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