Resmetirom Impurity 11 CAS CATO-C4X-291211
| CAS No. | CATO-C4X-291211 |
| Molecular Formula | C26H23Cl4N7O4 |
| Molecular Weight | 639.32 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Resmetirom Impurity 11 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Resmetirom Impurity 11 (CAS CATO-C4X-291211) is a certified pharmaceutical impurity reference standard with the molecular formula C26H23Cl4N7O4 and a molecular weight of 639.32 g/mol.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Resmetirom Impurity 11 is typically pale yellow to yellow amorphous powder. Its solid-state physicochemical attributes — including a molecular weight of 639.32 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C26H23Cl4N7O4 |
| Molecular Weight | 639.32 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 7 |
Related Resmetirom Standards
- Resmetirom impurity 88 (CAS CATO-C4X-291288)
- Resmetirom Impurity 97 (CAS CATO-C4X-291297)
- Resmetirom impurity 119 (CAS CATO-C4X-2912119)
- Resmetirom impurity 106 (CAS CATO-C4X-2912106)
- Resmetirom impurity 105 (CAS CATO-C4X-2912105)
- Resmetirom impurity 107 (CAS CATO-C4X-2912107)
- Resmetirom impurity 123 (CAS CATO-C4X-2912123)
- Resmetirom impurity 118 (CAS CATO-C4X-2912118)
Recommended Standards
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- (SP-5-13)-Chloro[[2,2′-[(1S,2S)-1,2-cyclohexanediylbis[(nitrilo-κN)methylidyne]]bis[4,6-bis(1,1-dimethylethyl)phenolato-κO]](2-)]cobalt (CAS 630404-46-5)
- [[(2R,3R,4R,5R)-5-[5-(benzylcarbamoyl)-2,4-dioxo-pyrimidin-1-yl]-3-hydroxy-4-methoxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate (CAS 1033909-23-7)
- Ruxolitinib Impurity 147 (CAS 2761879-41-6)
- Azilsartan Impurity 10 (CAS 1863930-34-0)
- Tirofiban Impurity 72 (CAS CATO-C4X-125472)
- 2-((Tert-butoxycarbonyl)amino)-2-(3,4-difluorophenyl)acetic acid (CAS 672961-72-7)
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- 3-(4-Fluorophenoxy)propanoyl chloride (CAS 710-36-1)
- 4-Chloro-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidine (CAS 3771-95-7)
- N-(4-(Allyloxy)benzyl)-1-(pyridin-3-yl)methanamine (CAS 774190-49-7)
- 2-Amino-8-bromo-6-nitroquinazolin-4(1H)-one (CAS 447415-80-7)
- Des-Tyr10-Tirzepatide (CAS CATO-CPTD788680)
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