Resmetirom impurity 125 CAS CATO-C4X-2912125
| CAS No. | CATO-C4X-2912125 |
| Molecular Formula | C20H19Cl4N5O |
| Molecular Weight | 487.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Resmetirom impurity 125 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Resmetirom impurity 125 (CAS CATO-C4X-2912125, C20H19Cl4N5O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C20H19Cl4N5O, Resmetirom impurity 125 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 487.21 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Resmetirom impurity 125 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C20H19Cl4N5O |
| Molecular Weight | 487.21 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Resmetirom Standards
- Resmetirom impurity 110 (CAS CATO-C4X-2912110)
- Resmetirom impurity 120 (CAS CATO-C4X-2912120)
- Resmetirom impurity 139 (CAS 1581304-53-1)
- Resmetirom impurity 16 (CAS 920509-33-7)
- Resmetirom Impurity 34 (CAS CATO-C4X-291234)
- Resmetirom Impurity 42 (CAS CATO-C4X-291242)
- Resmetirom impurity 84 (CAS CATO-C4X-291284)
- Resmetirom impurity 85 (CAS CATO-C4X-291285)
Recommended Standards
- 5-(Dimethoxymethyl)-5-propylimidazolidine-2,4-dione (CAS 7146-47-6)
- 1168092-22-5 A14380 (CAS 1168092-22-5)
- 1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl](methyl)amino}-3-methyl-4,5-dihydro-1H-1,2,4-triazol-5-one (CAS 860789-06-6)
- 2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-1-{4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}ethan-1-one (CAS 691858-19-2)
- Landiolol Impurity 35 (CAS CATO-C4X-262135)
- Remdesivir Impurity 46 (CAS CATO-C4X-210046)
- Glipizide Impurity 36 (CAS 933705-21-6)
- 3-Fluoro-3-(2-fluorophenyl)azetidine (CAS 1432792-73-8)
- 900169-53-1 Dichloro[1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene](benzylidene)bis(3-bromopyridine)ruthenium(II) [1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro(phenylmethylene)bis(3-bromopyridine)ruthenium(II) [1,3-Dimesityl-2-imidazolidinylidene]dichloro(phenylmethylene)bis(3-bromopyridine)ruthenium(II) (CAS 900169-53-1)
- 556050-49-8 N-[4-(1H,1H,2H,2H-Perfluorodecyl)benzyloxycarbonyloxy]succinimide N-[4-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-Heptadecafluorodecyl) benzyloxycarbonyloxy]succinimide (CAS 556050-49-8)
- 4-Chloro-N-(pyrimidin-5-ylmethyl)aniline (CAS 1343805-78-6)
- Methyl dimethylglycinate hydrochloride (CAS 1954-58-1)
- 2-(4-Bromo-3-(difluoromethyl)-5-iodopyridin-2-yl)acetic acid (CAS 1806873-14-2)
- Peptide Impurity 05 (CAS 2322924-83-2)
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