Resmetirom Impurity 42 CAS CATO-C4X-291242
| CAS No. | CATO-C4X-291242 |
| Molecular Formula | C19H18Cl2N6O5 |
| Molecular Weight | 481.29 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Resmetirom Impurity 42.
As a process- or degradation-related impurity, Resmetirom Impurity 42 (CAS CATO-C4X-291242, C19H18Cl2N6O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Resmetirom Impurity 42 (C19H18Cl2N6O5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Resmetirom Impurity 42 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H18Cl2N6O5 |
| Molecular Weight | 481.29 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
Related Resmetirom Standards
- Resmetirom impurity 139 (CAS 1581304-53-1)
- Resmetirom impurity 16 (CAS 920509-33-7)
- Resmetirom Impurity 34 (CAS CATO-C4X-291234)
- Resmetirom impurity 84 (CAS CATO-C4X-291284)
- Resmetirom Impurity 31 (CAS CATO-C4X-291231)
- Resmetirom impurity 125 (CAS CATO-C4X-2912125)
- Resmetirom impurity 112 (CAS CATO-C4X-2912112)
- Resmetirom impurity 56 (CAS 3033842-98-4)
Recommended Standards
- (3,4-Dichlorophenyl)(3-(((3-(trifluoromethyl)phenyl)thio)methyl)benzofuran-2-yl)methanone (CAS 400082-38-4)
- (5-(4-Fluorophenoxy)-1-methyl-3-phenyl-1H-pyrazol-4-yl)methyl 4-bromobenzoate (CAS 318289-24-6)
- methyl 3-methyl-2-[3-(1,1,2,2,3,3,4,4,4-nonafluorobutylsulfonyloxy)isoxazol-5-yl]butanoate (CAS 2378053-95-1)
- 5-(4-Bromophenyl)-4-(3-fluoro-4-methylbenzoyl)-3-hydroxy-1-(pyridin-3-ylmethyl)-1H-pyrrol-2(5H)-one (CAS 618073-90-8)
- Cenobamate Impurity 41 (CAS CATO-C4X-241641)
- Tadalafil Impurity 121 (CAS CATO-C4X-1087121)
- Methotrexate Impurity 63 (CAS 2801801-56-7)
- 2-tert-Butyl-3-Iodoimidazo[1,2-a]pyridine (CAS 1426142-81-5)
- Ethyl 5-thiomorpholino-3-(p-tolyl)-1,2,4-triazine-6-carboxylate (CAS 866051-68-5)
- Saxagliptin Impurity 79 (CAS CATO-C4X-104979)
- 2-Bromo-4-methoxy-5-benzyloxybenzoic acid (CAS 24958-42-7)
- Methyl 2-nitro-3-(trifluoromethyl)benzoate (CAS 1227511-70-7)
- 4-(3-(4-Nitrobenzyl)ureido)benzene-1-sulfonyl fluoride (CAS 21315-99-1)
- Semaglutide Impurity 189 (CAS CATO-C4X-2226189)
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