Resmetirom impurity 124 CAS CATO-C4X-2912124

Description

Compared with other compounds in its class, the molecular weight of 299.15 g/mol gives Resmetirom impurity 124 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

CATO supplies Resmetirom impurity 124 (CAS CATO-C4X-2912124), a pharmacopoeial impurity reference standard (molecular formula C13H12Cl2N2O2, MW 299.15 g/mol) used for the identification and quantification of trace impurities in APIs.

Resmetirom impurity 124 (C13H12Cl2N2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

As a certified reference material (CRM), Resmetirom impurity 124 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

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