Resmetirom Impurity 28 CAS CATO-C4X-291228

Purity >95%In StockPharmacopoeial Impurity Standards
CAS No.CATO-C4X-291228
Molecular FormulaC14H6Cl2N6O4
Molecular Weight393.14 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Resmetirom Impurity 28 CAS CATO-C4X-291228 chemical structure

Description

Compared with other compounds in its class, the molecular weight of 393.14 g/mol gives Resmetirom Impurity 28 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

Resmetirom Impurity 28 (CAS CATO-C4X-291228) is a certified pharmaceutical impurity reference standard with the molecular formula C14H6Cl2N6O4 and a molecular weight of 393.14 g/mol.

Resmetirom Impurity 28 (C14H6Cl2N6O4) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

As a certified reference material (CRM), Resmetirom Impurity 28 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC14H6Cl2N6O4
Molecular Weight393.14 g/mol
AppearancePale yellow to yellow crystalline powder. (slight halide-like odor, low volatility)
Purity>95%
StorageStore at 2-8°C, protect from light, keep sealed and dry
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)14.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
Halogen ContentCl-containing
Nitrogen Atoms6

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