Aripiprazole Impurity 17 CAS 1424857-89-5
| CAS No. | 1424857-89-5 |
| Molecular Formula | C16H17Cl4N3 |
| Molecular Weight | 393.14 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Aripiprazole Impurity 17 (CAS 1424857-89-5, C16H17Cl4N3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Aripiprazole Impurity 17 (C16H17Cl4N3) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H17Cl4N3 |
| Molecular Weight | 393.14 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Aripiprazole Standards
- Aripiprazole Impurity 46 (CAS CATO-C4X-100846)
- Aripiprazole Impurity 49 (CAS 882880-12-8)
- Aripiprazole Impurity 60 (CAS CATO-C4X-100860)
- Aripiprazole Impurity 47 (CAS CATO-C4X-100847)
- Aripiprazole EP Impurity D (CAS 203395-82-8)
- Aripiprazole EP Impurity C (CAS 203395-81-7)
- Aripiprazole Impurity 76 (CAS CATO-C4X-100876)
- Aripiprazole Impurity N17 (CAS 1076199-56-8)
Recommended Standards
- N-(2,4-Dichlorobenzyl)-2,2,2-trifluoro-N-(3-nitrophenyl)acetamide (CAS 313233-78-2)
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- 3-(4-Bromophenyl)-5-((phenylselanyl)methyl)isoxazole (CAS 833462-31-0)
- 3-(Tributylstannyl)-2-pyridinecarbonitrile (CAS 1416437-24-5)
- Proguanil EP Impurity F (CAS 537-21-3)
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- 4-Bromo-5-nitropyridin-2-amine (CAS 84487-11-6)
- TT-232 (CAS 147159-51-1)
- 6-(4-Methoxyphenyl)-3-(pyrrolidin-2-yl)-[1,2,4]triazolo[4,3-b]pyridazine (CAS 1706456-17-8)
- 3,4-Bis(2-(2-(2-(decyloxy)ethoxy)ethoxy)ethoxy)benzaldehyde (CAS 656821-30-6)
- 2-[2-(2-Chloro-7-methyl-3-quinolinyl)ethyl]-1h-isoindole-1,3(2H)-dione (CAS 1105193-61-0)
- Diflunisal Impurity 1 (CAS 705564-12-1)
- Insulin Degludec Impurity 11 (CAS CATO-C4X-215711)
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