Resmetirom impurity 136 CAS CATO-C4X-2912136
| CAS No. | CATO-C4X-2912136 |
| Molecular Formula | C16H14Cl2N6O3 |
| Molecular Weight | 409.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Resmetirom impurity 136 (CAS CATO-C4X-2912136) is a certified pharmaceutical impurity reference standard with the molecular formula C16H14Cl2N6O3 and a molecular weight of 409.23 g/mol.
Resmetirom impurity 136 (C16H14Cl2N6O3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO manufactures Resmetirom impurity 136 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C16H14Cl2N6O3 |
| Molecular Weight | 409.23 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
Related Resmetirom Standards
- Resmetirom Impurity 24 (CAS 2987937-25-5)
- Resmetirom impurity 90 (CAS CATO-C4X-291290)
- Resmetirom Impurity 21 (CAS 920509-34-8)
- Resmetirom Impurity 13 (CAS CATO-C4X-291213)
- Resmetirom Impurity 25 (CAS CATO-C4X-291225)
- Resmetirom impurity 122 (CAS 2639977-02-7)
- Resmetirom Impurity 29 (CAS CATO-C4X-291229)
- Resmetirom impurity 18 (CAS 1581304-52-0)
Recommended Standards
- 2-chloro-4-(2-chloro-N-cyclopropyl-4-(cyclopropylamino)pyrimidine-5-carboxamido)pyrimidine-5-carboxylic acid (CAS CATO-C3D-262478)
- HA 14-1, 95% (CAS 65673-63-4)
- (ΑR,4R)-rel-2-amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid, ethyl ester (CAS 927635-64-1)
- 1-(3-Bromophenyl)-3-(3-(p-tolyl)-1,2,4-oxadiazol-5-yl)pyridazin-4(1H)-one (CAS 1251582-33-8)
- Dalilesen Impurity 58 (CAS CATO-C4X-301058)
- Calcium Dobesilate Impurity N3 (CAS 17724-11-7)
- Nafamostat Impurity 8 (CAS CATO-C4X-13328)
- 2-((2-Nitrophenyl)amino)thiazol-4(5H)-one (CAS 692270-68-1)
- Methyl 5-((2-ethoxyphenyl)carbamoyl)-2-(4-fluorobenzamido)-4-methylthiophene-3-carboxylate (CAS 505096-33-3)
- 11-(4-Hydroxy-3-nitrophenyl)-3,3-dimethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one (CAS 886650-42-6)
- 1-(4-(4-Methoxy-3-nitrophenyl)thiazol-2-yl)guanidine (CAS 88540-92-5)
- 2-Amino-N,6-dimethyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide (CAS 1099624-26-6)
- tert-Butyl 4-(dimethylphosphoryl)-3,6-dihydropyridine-1(2H)-carboxylate (CAS 2694789-06-3)
- Thymopoietin II Peptide Fragment (CAS 56795-64-3)
Why CATO?
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- 130,000+ catalog items in stock, COA supplied with every batch
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