Resmetirom Impurity 33 CAS CATO-C4X-291233
| CAS No. | CATO-C4X-291233 |
| Molecular Formula | C17H12Cl2N6O4 |
| Molecular Weight | 435.22 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Resmetirom Impurity 33.
Resmetirom Impurity 33 (CAS CATO-C4X-291233) is a certified pharmaceutical impurity reference standard with the molecular formula C17H12Cl2N6O4 and a molecular weight of 435.22 g/mol.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Resmetirom Impurity 33 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 435.22 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H12Cl2N6O4 |
| Molecular Weight | 435.22 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
Related Resmetirom Standards
- Resmetirom (CAS 920509-32-6)
- Resmetirom Impurity 138 (CAS CATO-C4X-2912138)
- Resmetirom Impurity 32 (CAS CATO-C4X-291232)
- Resmetirom impurity 86 (CAS CATO-C4X-291286)
- Resmetirom impurity 87 (CAS CATO-C4X-291287)
- Resmetirom Impurity 46 (CAS CATO-C4X-291246)
- Resmetirom impurity 109 (CAS CATO-C4X-2912109)
- Resmetirom impurity 132 (CAS 2542038-65-1)
Recommended Standards
- Triphenylstannyldimethylvinylsilane (CAS 210362-73-5)
- Methyl 3-iodo-1-(3-methoxybenzoyl)-1H-indole-2-carboxylate (CAS 860651-20-3)
- Imidodicarbonic acid, (2-bromo-4-fluoro-6-nitrophenyl)-, bis(1,1-dimethylethyl) ester (CAS 880384-52-1)
- (1E)-1-[2-(3,4-Difluorophenoxy)phenyl]-N-(4-iodophenyl)methanimine (CAS 477886-91-2)
- Minodronic Acid Impurity 13 (CAS 127657-45-8)
- Avatrombopag Impurity 37 (CAS 17766-28-8)
- Lansoprazole Impurity 32 HCl (CAS 152402-94-3)
- 1-Benzyl-4-(2-chlorophenyl)pyrrolidine-3-carboxylic acid (CAS 939757-57-0)
- 2,8-Diamino-9-((2-hydroxyethoxy)methyl)-1H-purin-6(9H)-one (CAS 91898-00-9)
- 7-Bromo-4-[(4-methoxyphenyl)methyl]-2,3,4,5-tetrahydro-1,4-benzoxazepin-3-one (CAS 1326912-20-2)
- 2-(2-Fluorophenyl)benzoic acid (CAS 361-92-2)
- Sitagliptin Impurity 57 (CAS 1803026-58-5)
- 5-Bromo-2-methyl-2H-indazol-6-ol (CAS 2412816-06-7)
- semaglutide (CAS 782487-28-9)
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