Resmetirom Impurity 46 CAS CATO-C4X-291246
| CAS No. | CATO-C4X-291246 |
| Molecular Formula | C20H19Cl2N3O3 |
| Molecular Weight | 420.29 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Resmetirom Impurity 46.
Resmetirom Impurity 46 (CAS CATO-C4X-291246) is a certified pharmaceutical impurity reference standard with the molecular formula C20H19Cl2N3O3 and a molecular weight of 420.29 g/mol.
Based on its molecular formula C20H19Cl2N3O3, Resmetirom Impurity 46 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 420.29 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Resmetirom Impurity 46 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C20H19Cl2N3O3 |
| Molecular Weight | 420.29 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Resmetirom Standards
- Resmetirom impurity 18 (CAS 1581304-52-0)
- Resmetirom Impurity 47 (CAS CATO-C4X-291247)
- Resmetirom Impurity 25 (CAS CATO-C4X-291225)
- Resmetirom Impurity 13 (CAS CATO-C4X-291213)
- Resmetirom Impurity 21 (CAS 920509-34-8)
- Resmetirom impurity 136 (CAS CATO-C4X-2912136)
- Resmetirom Impurity 24 (CAS 2987937-25-5)
- Resmetirom impurity 90 (CAS CATO-C4X-291290)
Recommended Standards
- Diazoxide Impurity 14 (CAS CATO-C4X-195214)
- 7-Bromo-4-(3,4-diethoxybenzyl)-4,5-dihydrobenzo[f][1,4]oxazepin-3(2H)-one (CAS 1326864-81-6)
- Diazoxide Impurity 12 (CAS CATO-C4X-195212)
- 1-[(4-Bromophenyl)methyl]-3-(4-methylphenyl)-1H-indole-2-carboxylic acid (CAS 866155-19-3)
- Finerenone Impurity 188 (CAS CATO-C4X-2880188)
- Promethazine EP Impurity D (CAS 7640-51-9)
- Fudosteine impurity 73 (CAS CATO-C4X-144773)
- 1-(3-((2-Hydroxyethyl)(isopropyl)amino)piperidin-1-yl)ethanone (CAS 1353948-33-0)
- Fulvestrant Impurity 21 (CAS 261506-24-5)
- Methyl 5-chloro-2-naphthoate (CAS 127810-72-4)
- Methyl 1-aminocycloheptanecarboxylate (CAS 183429-63-2)
- 6-(Bromomethyl)-2-methylbenzo[d]thiazole (CAS 259862-37-8)
- Cesium sulfate (CAS 10294-54-9)
- Semaglutide impurity 237 (CAS CATO-C4X-2226237)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com