Resmetirom impurity 86 CAS CATO-C4X-291286
| CAS No. | CATO-C4X-291286 |
| Molecular Formula | C19H19ClN6O5 |
| Molecular Weight | 446.84 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Resmetirom impurity 86 is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Resmetirom impurity 86 (CAS CATO-C4X-291286), a pharmacopoeial impurity reference standard (molecular formula C19H19ClN6O5, MW 446.84 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Resmetirom impurity 86 (C19H19ClN6O5) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Resmetirom impurity 86 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H19ClN6O5 |
| Molecular Weight | 446.84 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
Related Resmetirom Standards
- Resmetirom Impurity 32 (CAS CATO-C4X-291232)
- Resmetirom impurity 87 (CAS CATO-C4X-291287)
- Resmetirom impurity 109 (CAS CATO-C4X-2912109)
- Resmetirom impurity 132 (CAS 2542038-65-1)
- Resmetirom Impurity 26 (CAS 2222607-69-2)
- Resmetirom Impurity 10 (CAS CATO-C4X-291210)
- Resmetirom impurity 137 (CAS CATO-C4X-2912137)
- Resmetirom impurity 14 (CAS 2542029-02-5)
Recommended Standards
- Demeclocycline EP Impurity G (CAS 22688-73-9)
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- Demeclocycline EP Impurity F (CAS CATO-C4X-16086)
- N-(5-Chloro-3-(phenylsulfonyl)-1H-indol-2-yl)-2,4-difluorobenzamide (CAS 918493-42-2)
- Amifostine Impurity 8 (CAS 33759-44-3)
- N-Nitroso Pseudoephedrine (N-Nitroso Ephedrine HCl EP Impurity B) (CAS 1850-88-0)
- Trientine Impurity 3 (CAS CATO-C4X-30683)
- 2-(5-(4-Chlorophenyl)-4H-1,2,4-triazol-3-yl)acetic acid (CAS 1203243-07-5)
- Salbutamol Impurity 141 (CAS CATO-C4X-1176141)
- (2,2-difluorocyclohexyl)methanamine hydrochloride (CAS 1780923-10-5)
- 2-(3-ethoxyphenoxy)-1,3-benzothiazol-6-amine (CAS 1491340-41-0)
- 3-(4-((2-Chloro-6-fluorobenzyl)oxy)phenyl)-1-((2,4-difluorophenyl)sulfonyl)-1H-pyrazole (CAS 477710-96-6)
- 1,4,5,8-Tetraamino-2,7-bis(2-methoxyethoxy)anthracene-9,10-dione (CAS 88601-71-2)
- Des-[Ser]8-Liraglutide (CAS CATO-C4X-199233)
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