Abemaciclib impurity 112 CAS CATO-C4X-2937112
| CAS No. | CATO-C4X-2937112 |
| Molecular Formula | C19H22ClFN4O |
| Molecular Weight | 376.86 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Abemaciclib impurity 112 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
As a process- or degradation-related impurity, Abemaciclib impurity 112 (CAS CATO-C4X-2937112, C19H22ClFN4O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Abemaciclib impurity 112 (C19H22ClFN4O) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C19H22ClFN4O |
| Molecular Weight | 376.86 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Abemaciclib Standards
- Abemaciclib Impurity 184 (CAS CATO-C4X-2937184)
- Abemaciclib Impurity 153 (CAS CATO-C4X-2937153)
- Abemaciclib Impurity 182 (CAS CATO-C4X-2937182)
- Abemaciclib Impurity 85 (CAS CATO-C4X-293785)
- Abemaciclib Impurity 3 (CAS CATO-C4X-29373)
- Abemaciclib Impurity 160 (CAS CATO-C4X-2937160)
- Abemaciclib impurity 113 (CAS CATO-C4X-2937113)
- Abemaciclib impurity 114 (CAS CATO-C4X-2937114)
Recommended Standards
- Etoricoxib Impurity 85 (CAS CATO-C4X-108085)
- ethyl N-[10-(3-chloropropanoyl)phenothiazin-2-yl]carbamate (CAS 34749-22-9)
- N-allyl-2-(1-(4-chlorobenzyl)-2-oxo-1,2-dihydropyridine-3-carbonyl)hydrazine-1-carbothioamide (CAS 400074-96-6)
- (R)-3-Chloro-1-phenyl-1-[2-methyl-4-[(tert-butoxycarbonyl)oxy]phenoxy] propane (CAS 457634-25-2)
- Etoricoxib impurity 60 (CAS 3724-43-4)
- Desloratadine Impurity 83 (CAS 26699-73-0)
- Dapagliflozin Impurity 164 (CAS CATO-C4X-1138164)
- 4-Chloro-3,3-dimethyl-3-fluorobutyrophenone (CAS 898764-64-2)
- 4-(1,3-Dithiolan-2-yl)-2-methoxy-6-nitrophenol (CAS 331460-87-8)
- 4,7-Difluorobenzo[d]thiazol-2(3H)-one, 97% (CAS 1188043-35-7)
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- 2-Methyl-1-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propan-1-one (CAS 2216004-10-1)
- Methyl 4-(3-chloropropanamido)benzoate (CAS 160313-42-8)
- Neuropeptide Y, human (CAS 98264-90-5)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com