Abemaciclib impurity 114 CAS CATO-C4X-2937114
| CAS No. | CATO-C4X-2937114 |
| Molecular Formula | C18H23Cl2N4 |
| Molecular Weight | 366.31 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Abemaciclib impurity 114 (CAS CATO-C4X-2937114), a pharmacopoeial impurity reference standard (molecular formula C18H23Cl2N4, MW 366.31 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Abemaciclib impurity 114 (C18H23Cl2N4) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.5, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 366.31 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Abemaciclib impurity 114 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C18H23Cl2N4 |
| Molecular Weight | 366.31 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Abemaciclib Standards
- Abemaciclib impurity 113 (CAS CATO-C4X-2937113)
- Abemaciclib Impurity 129 (CAS CATO-C4X-2937129)
- Abemaciclib Impurity 55 (CAS 2379819-71-1)
- Abemaciclib Impurity 163 (CAS CATO-C4X-2937163)
- Abemaciclib Impurity 85 (CAS CATO-C4X-293785)
- Abemaciclib Impurity 182 (CAS CATO-C4X-2937182)
- Abemaciclib Impurity 153 (CAS CATO-C4X-2937153)
- Abemaciclib Impurity 184 (CAS CATO-C4X-2937184)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com