Abemaciclib Impurity 133 CAS CATO-C4X-2937133
| CAS No. | CATO-C4X-2937133 |
| Molecular Formula | C25H28F2N8O |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Abemaciclib Impurity 133.
Abemaciclib Impurity 133 (CAS CATO-C4X-2937133) is a certified pharmaceutical impurity reference standard with the molecular formula C25H28F2N8OHCl and a molecular weight of 531.01 g/mol.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, Abemaciclib Impurity 133 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 531.01 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Abemaciclib Impurity 133 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C25H28F2N8O 2*HCl |
| Molecular Weight | 531.01 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 8 |
Related Abemaciclib Standards
- Abemaciclib Impurity N5 (CAS 1038408-36-4)
- Abemaciclib Impurity 21 (CAS 1178566-47-6 (free base))
- Abemaciclib (CAS 1231929-97-7)
- Abemaciclib Impurity N2 (CAS 1231930-29-2)
- Abemaciclib Impurity N4 (CAS 1231930-33-8)
- Abemaciclib Impurity N7 (CAS 1231930-37-2)
- Abemaciclib Impurity N3 (CAS 1231930-42-9)
- Abemaciclib Impurity 70 (CAS 1231930-47-4)
Recommended Standards
- Benserazide impurity 50 (CAS CATO-C4X-142750)
- Pitavastatin Impurity 17 Sodium Salt (Mixture of Diastereomers) (CAS CATO-C4X-103717)
- Ruxolitinib Impurity 233 (CAS CATO-C4X-2058233)
- 2-(2,5-Dichlorophenoxy)butanoic acid (CAS 855152-75-9)
- N-(5-Amino-6-methylbenzo[d]thiazol-2-yl)cyclohexanecarboxamide (CAS 324022-90-4)
- 1-Bromo-4-(4-chlorophenyl)-8-fluoroisoquinolin-3-amine (CAS 338761-94-7)
- 3-Phenethoxy-2-phenylquinazolin-4(3H)-one (CAS 300398-42-9)
- 2-Bromo-6-(cyanomethyl)-5-(difluoromethyl)nicotinonitrile (CAS 1804840-83-2)
- (R)-1-(2-Bromo-4-fluorophenyl)ethanamine hydrochloride (CAS 1624262-55-0)
- Tau Peptide (307-321) trifluoroacetate salt (CAS 330456-50-3)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com