Abemaciclib Impurity N4 CAS 1231930-33-8
| CAS No. | 1231930-33-8 |
| Molecular Formula | C11H12BrFN2 |
| Molecular Weight | 271.13 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Abemaciclib Impurity N4 (C11H12BrFN2) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/bromine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO supplies Abemaciclib Impurity N4 (CAS 1231930-33-8), a pharmacopoeial impurity reference standard (molecular formula C11H12BrFN2, MW 271.13 g/mol) used for the identification and quantification of trace impurities in APIs.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Abemaciclib Impurity N4 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H12BrFN2 |
| Molecular Weight | 271.13 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 2 |
Related Abemaciclib Standards
- Abemaciclib impurity 110 (CAS CATO-C4X-2937110)
- Abemaciclib Impurity 124 (CAS 2380322-35-8)
- Abemaciclib Impurity 127 (CAS 2922910-91-4)
- Abemaciclib Impurity 135 (CAS CATO-C4X-2937135)
- Abemaciclib Impurity 148 (CAS 1844847-62-6)
- Abemaciclib impurity 109 (CAS CATO-C4X-2937109)
- Abemaciclib Impurity 185 (CAS 871258-57-0)
- Abemaciclib Impurity 128 (CAS CATO-C4X-2937128)
Recommended Standards
- N-(benzo[d]thiazol-2-yl)-2-bromoacetamide (CAS 121189-77-3)
- 5-Bromo-1-butyl-6-fluorobenzoimidazole, HCl (CAS 1261906-10-8)
- 5-Bromo-1-tert-butyl-6-fluorobenzoimidazole (CAS 1187385-67-6)
- 8-Bromo-7,8-dihydropyrrolo[1,2-a]thieno[2,3-d]pyrimidin-4(6h)-one (CAS 1375473-27-0)
- Lumefantrine Impurity 2 (CAS 355841-11-1(Free base))
- Furosemide Impurity 19 (CAS CATO-C4X-140219)
- Omeprazole Impurity 6 (CAS CATO-C4X-12556)
- Ethyl 5-bromo-2-cyanobenzoate (CAS 127510-93-4)
- 2-Amino-5H-thiazolo[3,2-a]pyridin-5-one (CAS 2387596-62-3)
- Cholesterol Impurity 39 (CAS 17137-70-1)
- N-(3-Ethynylphenyl)-7-methoxy-6-nitroquinazolin-4-amine (CAS 183321-60-0)
- 5-Methyl-2-[3-(trifluoromethyl)phenyl]oxazole-4-carboxylic Acid (CAS 848188-39-6)
- 1-(4-Hydroxy-5-methoxy-2-nitrophenyl)cyclobutane-1-carbonitrile (CAS 1527503-23-6)
- Galanin Message Associated Peptide (44-59) amide (CAS 125455-59-6)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com