Abemaciclib Impurity 168 CAS CATO-C4X-2937168
| CAS No. | CATO-C4X-2937168 |
| Molecular Formula | C16H20ClFN6 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO supplies Abemaciclib Impurity 168 (CAS CATO-C4X-2937168), a pharmacopoeial impurity reference standard (molecular formula C16H20ClFN6HCl, MW 387.28 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Abemaciclib Impurity 168 (C16H20ClFN6HCl) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 387.28 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H20ClFN6 3*HCl |
| Molecular Weight | 387.28 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 6 |
Related Abemaciclib Standards
- Abemaciclib Impurity N5 (CAS 1038408-36-4)
- Abemaciclib Impurity 21 (CAS 1178566-47-6 (free base))
- Abemaciclib (CAS 1231929-97-7)
- Abemaciclib Impurity N2 (CAS 1231930-29-2)
- Abemaciclib Impurity N4 (CAS 1231930-33-8)
- Abemaciclib Impurity N7 (CAS 1231930-37-2)
- Abemaciclib Impurity N3 (CAS 1231930-42-9)
- Abemaciclib Impurity 70 (CAS 1231930-47-4)
Recommended Standards
- Tipiracil Impurity 6 Chloride (CAS CATO-C4X-100511)
- Bambuterol Impurity 10 (CAS CATO-C4X-274610)
- Tetrabenazine Impurity 66 (CAS CATO-C4X-274866)
- 5,6-Diamino-3-methylpyrimidin-4(3H)-one (CAS 89181-83-9)
- tert-Butyl 4-(2-(morpholine-4-carbonyl)phenoxy)piperidine-1-carboxylate (CAS 1146080-02-5)
- (5-Ethylfuran-2-yl)(4-(2-hydroxyethyl)piperazin-1-yl)methanone (CAS 1153278-95-5)
- 2-(3-Aminotetrahydro-2h-thiopyran-3-yl)acetic acid (CAS 1340239-98-6)
- 4-Amino-1-(3-chlorophenyl)pyrimidin-2(1H)-one (CAS 1416438-32-8)
- Rac-tert-butyl n-[(1r,2r)-2-aminocycloheptyl]carbamate, trans (CAS 1305711-56-1)
- Semaglutide impurity 107 (CAS CATO-C4X-2226107)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com