Pyronaridine Impurity 1 CAS CATO-C4X-29781
| CAS No. | CATO-C4X-29781 |
| Molecular Formula | C15H13ClN2O2 |
| Molecular Weight | 288.73 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Pyronaridine Impurity 1 is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Pyronaridine Impurity 1 (CAS CATO-C4X-29781) is a certified pharmaceutical impurity reference standard with the molecular formula C15H13ClN2O2 and a molecular weight of 288.73 g/mol.
Pyronaridine Impurity 1 (C15H13ClN2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Pyronaridine Impurity 1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H13ClN2O2 |
| Molecular Weight | 288.73 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Pyronaridine Standards
- Pyronaridine Impurity 16 (CAS 81935-64-0)
- Pyronaridine Impurity 10 (CAS 6626-40-0)
- Pyronaridine Impurity 12 (CAS CATO-C4X-297812)
- Pyronaridine Impurity 2 (CAS 1422180-92-4)
- Pyronaridine Impurity 7 (CAS CATO-C4X-29787)
- Pyronaridine Impurity 3 (CAS CATO-C4X-29783)
- Pyronaridine Impurity 11 (CAS CATO-C4X-297811)
- Pyronaridine Impurity 20 (CAS CATO-C4X-297820)
Recommended Standards
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- (2E)-3-(2-Chloro-6-fluorophenyl)-1-(2,4-dimethylphenyl)prop-2-en-1-one (CAS 1354942-37-2)
- Zopiclone Impurity 18 (CAS 349125-10-6)
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