Pyronaridine Impurity 16 CAS 81935-64-0
| CAS No. | 81935-64-0 |
| Molecular Formula | C12H5Cl3N2 |
| Molecular Weight | 283.54 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Pyronaridine Impurity 16 (CAS 81935-64-0), a pharmacopoeial impurity reference standard (molecular formula C12H5Cl3N2, MW 283.54 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution, Pyronaridine Impurity 16 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 283.54 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Pyronaridine Impurity 16 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H5Cl3N2 |
| Molecular Weight | 283.54 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1980 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Pyronaridine Standards
- Pyronaridine Impurity 10 (CAS 6626-40-0)
- Pyronaridine Impurity 12 (CAS CATO-C4X-297812)
- Pyronaridine Impurity 1 (CAS CATO-C4X-29781)
- Pyronaridine Impurity 2 (CAS 1422180-92-4)
- Pyronaridine Impurity 3 (CAS CATO-C4X-29783)
- Pyronaridine Impurity 20 (CAS CATO-C4X-297820)
- Pyronaridine Impurity 7 (CAS CATO-C4X-29787)
- Pyronaridine Impurity 11 (CAS CATO-C4X-297811)
Recommended Standards
- 2-aminononadecane 31604-55-4 TR-013407 (CAS 31604-55-4)
- Fenoprop-Methyl Ester (CAS 4841-20-7)
- 3002-57-1 N,N-Dimethylheptadecylamine 1-Heptadecanamine, N,N-dimethyl- EINECS 221-097-8 (CAS 3002-57-1)
- 5-Bromo-2-[3-(chloromethyl)phenyl]pyrimidine (CAS 1100598-50-2)
- Alogliptin Impurity 7-d3 (CAS 1268836-55-0（unlabelled）)
- Clotrimazole Impurity 26 (CAS 29921-41-3)
- Ursodeoxycholic Acid impurity 100 (CAS CATO-C4X-1422100)
- N-Butyl-4-(thiazol-2-yloxy)benzamide (CAS 2034225-85-7)
- Methyl (R)-2-((tert-butoxycarbonyl)amino)hex-5-enoate (CAS 221318-99-6)
- (2S,4S)-1-Boc-2-[4-(4-bromophenyl)-2-imidazolyl]-4-methylpyrrolidine (CAS 1250939-45-7)
- 1,4,5-Trimethyl-1H-pyrrole-2-carbonitrile (CAS 70319-58-3)
- 2-Amino-5,7-dimethyl-5,6,7,8-tetrahydroquinoline-3-carbonitrile (CAS 1343652-35-6)
- (4-Amino-5-bromopyridin-3-yl)methanol (CAS 1806995-45-8)
- Semaglutide Impurity 186 (CAS CATO-C4X-2226186)
Why CATO?
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