Belumosudil Impurity 44 CAS CATO-C4X-298844
| CAS No. | CATO-C4X-298844 |
| Molecular Formula | C18H16ClN3O2 |
| Molecular Weight | 341.79 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 341.79 g/mol gives Belumosudil Impurity 44 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Belumosudil Impurity 44 (CAS CATO-C4X-298844, C18H16ClN3O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Belumosudil Impurity 44 (C18H16ClN3O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 341.79 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Belumosudil Impurity 44 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H16ClN3O2 |
| Molecular Weight | 341.79 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Belumosudil Standards
- Belumosudil Impurity 38 (CAS CATO-C4X-298838)
- Belumosudil Impurity 39 (CAS 2121561-39-3)
- Belumosudil Impurity 29 (CAS CATO-C4X-298829)
- Belumosudil Impurity 61 (CAS CATO-C4X-298861)
- Belumosudil Impurity 59 (CAS CATO-C4X-298859)
- Belumosudil Impurity 62 (CAS CATO-C4X-298862)
- Belumosudil Impurity 33 (CAS 2121561-37-1)
- Belumosudil Impurity 43 (CAS 2121561-41-7)
Recommended Standards
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- Methyl 2-(4-ethynylphenoxy)acetate (CAS 178321-68-1)
- 8-Bromo-2-(ethylsulfonyl)-6-methyl-4H-chromen-4-one (CAS 2715284-55-0)
- 1,1-Difluoro-3-(iodomethyl)cyclopentane (CAS 1042153-28-5)
- 3-Amino-3-methyl-1-butanol Hydrochloride (CAS 357185-97-8)
- (2E)-3-(3-ethoxy-4-methoxyphenyl)acrylic acid (CAS 854883-46-8)
- Insulin Degludec Impurity 27 (CAS CATO-C4X-215727)
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