Ribociclib impurity 1 CAS CATO-C4X-31001
| CAS No. | CATO-C4X-31001 |
| Molecular Formula | C23H28N10O3 |
| Molecular Weight | 492.53 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Ribociclib impurity 1 (C23H28N10O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 15.0, corresponding to approximately 15 ring(s) or double-bond equivalent(s). With a molecular weight of 492.53 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Ribociclib impurity 1 (CAS CATO-C4X-31001, C23H28N10O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C23H28N10O3 |
| Molecular Weight | 492.53 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 10 |
Related Ribociclib Standards
- Ribociclib Impurity 21 (CAS CATO-C4X-310021)
- Ribociclib Impurity 41 (CAS CATO-C4X-310041)
- Ribociclib Impurity 44 (CAS CATO-C4X-310044)
- Ribociclib Impurity 20 (CAS CATO-C4X-310020)
- Ribociclib Impurity 19 (CAS CATO-C4X-310019)
- Ribociclib Impurity 23 (CAS CATO-C4X-310023)
- Ribociclib Impurity 10 (CAS CATO-C4X-310010)
- Ribociclib impurity 2 (CAS CATO-C4X-31002)
Recommended Standards
- Terazosin EP Impurity E (CAS 102839-00-9)
- Vazegepant Impurity 45 (CAS CATO-C4X-320045)
- Triamcinolone Acetonide Impurity 37 (CAS 72559-83-2)
- (R)-2-((3aR,5S,6S,6aR)-6-(benzyloxy)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)-2-((methylsulfonyl)oxy)ethyl benzoate (CAS 134198-40-6)
- Imipenem Impurity 131 (CAS CATO-C4X-1662131)
- Ceftazidime Impurity 16 (CAS 86299-47-0)
- ZHC-116 Impurity 6 (CAS CATO-C4X-23886)
- Methyl 4-bromo-3-hydroxy-5-(prop-2-yn-1-yloxy)thiophene-2-carboxylate (CAS 1707391-84-1)
- 1-(Morpholine-4-sulfonyl)piperidin-3-amine hydrochloride (CAS 1315365-90-2)
- 4-(4-Chlorophenyl)-2-(4-fluorophenoxy)pyrimidine (CAS 478080-79-4)
- Lumateperone Impurity 47 (CAS CATO-C4X-220147)
- (1R)-trans-Tetramethrin (CAS 1166-46-7)
- Ammonium 2,3-bis(tetradecanoyloxy)propyl (2,3-dihydroxypropyl) phosphate (CAS 108321-03-5)
- Semaglutide Impurity 186 (CAS CATO-C4X-2226186)
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