Ribociclib Impurity 35 CAS CATO-C4X-310035
| CAS No. | CATO-C4X-310035 |
| Molecular Formula | C12H13ClN4O2 |
| Molecular Weight | 280.71 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Ribociclib Impurity 35 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Ribociclib Impurity 35 (CAS CATO-C4X-310035), a pharmacopoeial impurity reference standard (molecular formula C12H13ClN4O2, MW 280.71 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C12H13ClN4O2, Ribociclib Impurity 35 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 280.71 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C12H13ClN4O2 |
| Molecular Weight | 280.71 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Ribociclib Standards
- Ribociclib Impurity 28 (CAS CATO-C4X-310028)
- Ribociclib Impurity 14 (CAS 1331847-17-6)
- Ribociclib impurity 39 (CAS 2304957-86-4)
- Ribociclib Impurity 29 (CAS CATO-C4X-310029)
- Ribociclib Impurity 15 (CAS CATO-C4X-310015)
- Ribociclib Impurity 33 (CAS CATO-C4X-310033)
- Ribociclib Impurity 36 (CAS 2387711-02-4)
- Ribociclib Impurity 27 (CAS 1298101-40-2)
Recommended Standards
- Domperidone Impurity 29 (CAS CATO-C4X-142029)
- 3-Chloro-N,N-dipropyl-5-(trifluoromethyl)-2-pyridinamine (CAS 1220029-34-4)
- Brexpiprazole Impurity 140 (CAS CATO-C4X-1131140)
- [2-amino-1-(4-chlorophenyl)ethyl](methyl)(3,3,3-trifluoropropyl)amine (CAS 1466767-16-7)
- Posaconazole Impurity 6 (CAS 149809-42-7)
- Apalutamide Impurity 26 (CAS CATO-C4X-274926)
- Milrinone Impurity 28 (CAS CATO-C4X-109128)
- 3-{[(9-ethyl-9H-carbazol-3-yl)methyl]amino}propan-1-ol (CAS 1157070-06-8)
- 1-(4-Chlorophenyl)-2-({5-[(2-phenoxyethyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)ethan-1-one (CAS 303988-42-3)
- 2-(Difluoromethyl)-3-methyl-4-nitro-5-(trifluoromethoxy)pyridine (CAS 1806260-20-7)
- 5-Bromo-4-chloro-2-fluorobenzoyl chloride (CAS 1070892-56-6)
- Methyl 1H-benzo[d]imidazol-2-ylcarbamate hydrochloride (CAS 23424-47-7)
- 3-Bromo-5-chloro-4-(difluoromethyl)pyridine (CAS 1335053-06-9)
- Acetyl Hexapeptide-39 (CAS 1382088-38-1)
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