Morpholine Impurity 9 CAS CATO-C4X-31689
| CAS No. | CATO-C4X-31689 |
| Molecular Formula | C12H11F4NO3 |
| Molecular Weight | 293.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Morpholine Impurity 9 (CAS CATO-C4X-31689, C12H11F4NO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Morpholine Impurity 9 (C12H11F4NO3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Morpholine Impurity 9 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C12H11F4NO3 |
| Molecular Weight | 293.21 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Morpholine Standards
- 3-(Morpholine-4-carboxamido)phenyl dimethylcarbamate (CAS 526190-24-9)
- Methyl (morpholine-4-carbonyl)-L-phenylalaninate (CAS 114473-20-0)
- Methyl 3-(morpholine-4-carbonyl)-5-nitrobenzoate (CAS 348593-54-4)
- 5-(Morpholine-4-carbonyl)-1-(thiophen-2-ylmethyl)pyrrolidin-2-one (CAS 477768-21-1)
- 2-[5-(morpholine-4-sulfonyl)thiophen-2-yl]acetic acid (CAS 309282-76-6)
- 5-(Morpholine-4-sulfonyl)-1H-indole-2,3-dione (CAS 220510-03-2)
- 7-(morpholine-4-sulfonyl)-1,2,3,4-tetrahydroisoquinolin-1-one (CAS 1803598-98-2)
- 2-(Morpholine-4-carbonyl)benzene-1-sulfonyl chloride (CAS 1016503-60-8)
Recommended Standards
- N-cyclohexyl-3,3,3-trifluoro-2-hydroxy-2-(trifluoromethyl)propanamide (CAS 1980087-10-2)
- 4-[(3,5-difluorobenzene)amido]-2-hydroxybenzoic acid (CAS 1019114-54-5)
- Methyl 3-(2-fluorophenyl)-3-[(2,2,2-trifluoroacetyl)amino]propanoate (CAS 866050-44-4)
- [1-(tert-Butyldimethylsilanyl)-5-fluoro-1H-indol-4-yl]boronic acid (CAS 1093066-72-8)
- Mirogabalin Impurity N87 (CAS 2165847-73-2)
- Nicotinamide EP Impurity D (CAS 1453-82-3)
- Ruxolitinib Impurity 89 (CAS CATO-C4X-205889)
- (2-Chlorophenyl)(2-((4-chlorophenyl)sulfonyl)benzyl)sulfane (CAS 337923-91-8)
- N-(Aminooxyacetyl)-N'-D-biotinoyl)hydrazine, 96% (CAS 139585-03-8)
- 1-Bromo-3-chloro-2-fluoro-5-methylbenzene (CAS 1780248-94-3)
- 3-((3-Aminopiperidin-1-yl)sulfonyl)-1-methylpyridin-2(1H)-one (CAS 1713639-43-0)
- 4-Bromo-3-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole (CAS 1563531-47-4)
- Methyl 4-(tert-butoxy)benzoate (CAS 62370-08-5)
- Liraglutide Impurity 26 (CAS CATO-C4X-199226)
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