Anlotinib Impurity 1 CAS CATO-C4X-32831
| CAS No. | CATO-C4X-32831 |
| Molecular Formula | C31H28FN3O5 |
| Molecular Weight | 541.57 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 541.57 g/mol gives Anlotinib Impurity 1 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Anlotinib Impurity 1 (CAS CATO-C4X-32831) is a certified pharmaceutical impurity reference standard with the molecular formula C31H28FN3O5 and a molecular weight of 541.57 g/mol.
Structurally, Anlotinib Impurity 1 (C31H28FN3O5) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 19.0, corresponding to approximately 19 ring(s) or double-bond equivalent(s). With a molecular weight of 541.57 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C31H28FN3O5 |
| Molecular Weight | 541.57 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 19.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Anlotinib Standards
Recommended Standards
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- Tegoprazan Impurity 28 (CAS CATO-C4X-229728)
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- Tegoprazan Impurity 18 (CAS 942485-42-9)
- Dexrazoxane Impurity 3 (CAS CATO-C4X-20203)
- Memantine Impurity 28 (CAS 63971-25-5)
- Diltiazem EP Impurity F HCl (CAS 75472-91-2(free base))
- 1-Cyano-5,6,7,8-tetrahydroindolizine-3-carboxylic acid (CAS 2138098-18-5)
- 5-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole (CAS 2448157-13-7)
- 3-Acetylthiophene-2-carboxylic acid (CAS 13657-90-4)
- 5-Amino-1-(tert-butyl)-3-phenyl-1H-pyrazole-4-carbonitrile (CAS 180903-09-7)
- 2-amino-3-nitropyridine-4-carboxylic acid (CAS 1795298-56-4)
- 3-(2,6-Dichlorophenyl)-5-methylisoxazole-4-carbothioamide (CAS 175204-43-0)
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