Anlotinib Impurity 2 CAS CATO-C4X-32832
| CAS No. | CATO-C4X-32832 |
| Molecular Formula | C31H28FN3O6 |
| Molecular Weight | 557.57 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Anlotinib Impurity 2 (CAS CATO-C4X-32832, C31H28FN3O6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Anlotinib Impurity 2 (C31H28FN3O6) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C31H28FN3O6 |
| Molecular Weight | 557.57 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 19.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Anlotinib Standards
Recommended Standards
- Capecitabine Impurity 21 (CAS CATO-C4X-102421)
- MK-3207 (CAS 957118-49-9)
- Cefminox Impurity 37 (CAS CATO-C4X-192637)
- II-B08 (CAS 1143579-78-5)
- Aztreonam impurity 80 (CAS CATO-C4X-152280)
- Posaconazole Impurity 145 (CAS CATO-C4X-1208145)
- Atropine Impurity 37 (CAS 35721-90-5)
- 6-(Thiophen-2-yl)pyridazine-3-thiol (CAS 134252-09-8)
- N-(3-Bromobenzyl)propionamide (CAS 915923-10-3)
- tert-Butyl 3-bromo-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate (CAS 1784831-22-6)
- Di-tert-butyl 2-(pyridin-2-yl)malonate (CAS 1104643-39-1)
- (S)-Methyl 6-amino-2-(((benzyloxy)carbonyl)amino)hexanoate (CAS 5591-93-5)
- APY0201 (CAS 1232221-74-7)
- Des-Gln24-Tirzepatide (CAS CATO-CPTD788949)
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