Capivasertib Impurity 46 CAS CATO-C4X-331246
| CAS No. | CATO-C4X-331246 |
| Molecular Formula | C19H20Cl2N2O3 |
| Molecular Weight | 395.28 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Capivasertib Impurity 46 (CAS CATO-C4X-331246) is a certified pharmaceutical impurity reference standard with the molecular formula C19H20Cl2N2O3 and a molecular weight of 395.28 g/mol.
The molecular framework of Capivasertib Impurity 46 (C19H20Cl2N2O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Capivasertib Impurity 46 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H20Cl2N2O3 |
| Molecular Weight | 395.28 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Capivasertib Standards
- Capivasertib Impurity 20 (CAS CATO-C4X-331220)
- Capivasertib Impurity 28 (CAS CATO-C4X-331228)
- Capivasertib Impurity 5 (CAS CATO-C4X-33125)
- Capivasertib Impurity 25 (CAS CATO-C4X-331225)
- Capivasertib (CAS 1143532-39-1)
- Capivasertib Impurity 1 (CAS 1143532-51-7)
- Capivasertib Impurity N1 (CAS 956460-96-1)
- Capivasertib Impurity 32 (CAS CATO-C4X-331232)
Recommended Standards
- N-(1-(3,4-dichlorobenzyl)-2-oxo-1,2-dihydropyridin-3-yl)-4-methylpiperazine-1-carboxamide (CAS 338755-44-5)
- 4-Bromo-9,9'-spirobi[fluorene] (CAS 1161009-88-6)
- 5-(3-Chlorophenyl)-2-(4-chlorophenyl)-5,10b-dihydro-1H-benzo[e]pyrazolo[1,5-c][1,3]oxazine (CAS 302914-18-7)
- 3-Bromo-9,9'-spirobi[fluorene] (CAS 1361227-58-8)
- Vincamine Impurity 1 (CAS 42971-12-0)
- Aprepitant Impurity 2 (CAS 1185502-97-9)
- Paraben Impurity 4 (CAS CATO-C4X-25694)
- 4-Allyl-5-(3-(dimethylamino)phenyl)-4H-1,2,4-triazole-3-thiol (CAS 860792-65-0)
- 1-(5-Bromothiophen-3-yl)-2,2,2-trifluoroethanol (CAS 1314894-44-4)
- Ethyl 2-amino-3-cyano-5,6,7,8-tetrahydroindolizine-1-carboxylate (CAS 178306-95-1)
- 2-(Chloromethyl)-8-methyl-4H-pyrido[1,2-a]pyrimidin-4-one (CAS 87591-84-2)
- N-(Piperidin-4-yl)pyrimidin-4-amine dihydrochloride (CAS 1448854-73-6)
- 4-Hydroxy-2-oxo-1-pentyl-N-(p-tolyl)-1,2-dihydroquinoline-3-carboxamide (CAS 300716-18-1)
- Semaglutide Impurity 147 (CAS CATO-C4X-2226147)
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