Aprepitant Impurity 2 CAS 1185502-97-9
| CAS No. | 1185502-97-9 |
| Molecular Formula | C23H21F7N4O3 |
| Molecular Weight | 534.43 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Aprepitant Impurity 2 (CAS 1185502-97-9, C23H21F7N4O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C23H21F7N4O3, Aprepitant Impurity 2 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 534.43 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C23H21F7N4O3 |
| Molecular Weight | 534.43 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Aprepitant Standards
- Aprepitant (CAS 170729-80-3)
- Aprepitant USP Related Compound A (CAS 1148113-53-4)
- Aprepitant Impurity 3 (CAS 172822-28-5)
- Aprepitant Impurity 4 (CAS 172822-29-6)
- Aprepitant Impurity 5 (CAS 1242175-40-1)
- Aprepitant Impurity 6 (CAS 170902-81-5)
- Aprepitant impurity 66 (CAS CATO-C4X-114166)
- Aprepitant Impurity 7 (CAS 1242175-34-3)
Recommended Standards
- Perfluorophenyl (((9H-fluoren-9-yl)methoxy)carbonyl)-D-glutaminate (CAS 200622-33-9)
- 5-[[(2S,3R)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one (CAS 221350-96-5)
- 2-((5-(5-Bromo-2-hydroxyphenyl)-4-(2,4-dimethylphenyl)-4H-1,2,4-triazol-3-yl)thio)-N-(2-cyanophenyl)acetamide (CAS 875006-54-5)
- Luteoline-7-malonylglucoside (CAS 98767-38-5)
- Menaquinone impurity 34 (CAS CATO-C4X-207634)
- CAS 2069210-84-8 (CAS 2069210-84-8)
- Rosuvastatin EP Impurity B(Calcium Salt) (CAS CATO-C4X-11692)
- 3-(4-Chlorophenyl)-2-methylacrylic acid (CAS 66482-40-4)
- 5,6-Dimethoxyquinolin-8-amine (CAS 6938-02-9)
- 3,4-Dimethoxypyrrolidine (CAS 55619-48-2)
- 4,6-Difluoro-7-methyl-1H-indole (CAS 1167056-29-2)
- (2R)-2-(morpholin-4-yl)propan-1-ol (CAS 1568171-26-5)
- tert-Butyl (S)-(1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethyl)carbamate (CAS 1171897-03-2)
- Semaglutide impurity 276 (CAS CATO-C4X-2226276)
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