Ledipasvir Impurity 27 CAS CATO-C4X-331327
| CAS No. | CATO-C4X-331327 |
| Molecular Formula | C27H26BrF2NO5 |
| Molecular Weight | 562.40 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Ledipasvir Impurity 27 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Ledipasvir Impurity 27 (CAS CATO-C4X-331327, C27H26BrF2NO5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Ledipasvir Impurity 27 (C27H26BrF2NO5) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution. The molecule exhibits a degree of unsaturation (DBE) of 14.0, corresponding to approximately 14 ring(s) or double-bond equivalent(s). With a molecular weight of 562.40 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C27H26BrF2NO5 |
| Molecular Weight | 562.40 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 1 |
Related Ledipasvir Standards
- Ledipasvir Impurity 28 (CAS CATO-C4X-331328)
- Ledipasvir Impurity 4 (CAS CATO-C4X-33134)
- Ledipasvir Impurity 7 (CAS 1441670-89-8)
- Ledipasvir Impurity 26 (CAS CATO-C4X-331326)
- Ledipasvir Impurity 38 (CAS CATO-C4X-331338)
- Ledipasvir Impurity-3 (CAS 1256388-50-7)
- Ledipasvir Impurity 13 (CAS CATO-C4X-331313)
- Ledipasvir Impurity 9 (CAS CATO-C4X-33139)
Recommended Standards
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