Ledipasvir Impurity 40 CAS CATO-C4X-331340
| CAS No. | CATO-C4X-331340 |
| Molecular Formula | C13H7BrF2 |
| Molecular Weight | 281.10 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Ledipasvir Impurity 40 (CAS CATO-C4X-331340, C13H7BrF2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Ledipasvir Impurity 40 (C13H7BrF2) contains fluorine/bromine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Ledipasvir Impurity 40 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H7BrF2 |
| Molecular Weight | 281.10 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Br-containing |
Related Ledipasvir Standards
- Ledipasvir Impurity 29 (CAS CATO-C4X-331329)
- Ledipasvir Impurity 30 (CAS CATO-C4X-331330)
- Ledipasvir Impurity 31 (CAS CATO-C4X-331331)
- Ledipasvir Impurity 32 (CAS CATO-C4X-331332)
- Ledipasvir Impurity 52 (CAS CATO-C4X-331352)
- Ledipasvir Impurity 8 (CAS CATO-C4X-33138)
- Ledipasvir Impurity 34 (CAS CATO-C4X-331334)
- Ledipasvir Impurity 19 (CAS CATO-C4X-331319)
Recommended Standards
- Methyl 6-bromo-1-hydroxy-2-naphthoate (CAS 2119959-89-4)
- 5-(3-bromophenyl)-1h-pyraZole-3-carbohydrazide (CAS 1046463-50-6)
- Methyl 5-(3-bromophenyl)furan-2-carboxylate (CAS 54023-08-4)
- N-(5-Bromo-[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide (CAS 1142943-96-1)
- Budesonide Impurity 68 (CAS 74220-43-2)
- Rtitrexed Impurity 27 (CAS CATO-C4X-138627)
- Loratadine EP Impurity G (CAS 38092-89-6)
- 1-(3-Thiomorpholinopyrazin-2-yl)-1H-pyrazole-3-carboxylic acid (CAS 1708428-45-8)
- 7-Bromo-2-methyl-2H-indazole-3-carboxylic acid (CAS 701910-30-7)
- Methyl 4-(1-phenylethyl)-1H-pyrrole-3-carboxylate (CAS 1313712-50-3)
- 2-Chloro-4-hydroxybenzamide (CAS 1046818-83-0)
- Pomalidomide Impurity 6 (CAS 24666-56-6)
- 8-Fluoro-4-hydroxy-6-methylquinoline-3-carbonitrile (CAS 61338-24-7)
- Semaglutide Impurity 167 (CAS CATO-C4X-2226167)
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