Loratadine EP Impurity G CAS 38092-89-6
| CAS No. | 38092-89-6 |
| Molecular Formula | C20H21ClN2 |
| Molecular Weight | 324.85 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 324.85 g/mol gives Loratadine EP Impurity G distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Loratadine EP Impurity G (CAS 38092-89-6, C20H21ClN2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution, Loratadine EP Impurity G is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 324.85 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Loratadine EP Impurity G under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C20H21ClN2 |
| Molecular Weight | 324.85 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1967 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Loratadine Standards
- Loratadine Impurity 30 (CAS 1346600-30-3)
- Loratadine Impurity 94 (CAS CATO-C4X-142694)
- Loratadine Impurity 77 (CAS 170727-68-1)
- Loratadine Impurity 53 (CAS 107285-30-3)
- Loratadine Impurity 76 (CAS CATO-C4X-142676)
- Loratadine EP Impurity D (CAS 100643-71-8)
- Loratadine Impurity 98 (CAS CATO-C4X-142698)
- Loratadine Impurity 99 (CAS CATO-C4X-142699)
Recommended Standards
- Roxatidine Impurity 30 (CAS CATO-C4X-121330)
- Desloratadine Impurity 30 (CAS 183198-48-3)
- Tert-butyl 4-amino-4-(4-chlorobenzyl)piperidine-1-carboxylate (CAS 956460-41-6)
- Desloratadine Impurity 33 (CAS 38092-90-9)
- Dotinurad Impurity 148 (CAS CATO-C4X-2494148)
- Pretomanid Impurity 9 (CAS CATO-C4X-26069)
- Carbocisteine Impurity 35 (CAS CATO-C4X-201035)
- 3-Phenyl-9-azabicyclo[3.3.1]nonan-3-ol (CAS 125834-96-0)
- 2,6-Dibromo-4-(difluoromethyl)pyridine-3-sulfonamide (CAS 1806891-17-7)
- 1H-pyrazolo[4,3-d]pyrimidine-3-carbonitrile (CAS 2104345-90-4)
- 4,4,4-Trifluoro-n-methoxy-n-methylbutanamide (CAS 368209-86-3)
- Ethyl 3-(4-iodophenyl)-1H-1,2,4-triazole-5-carboxylate (CAS 1285291-39-5)
- 5-(tert-Butyl)-2,4-dichlorothieno[2,3-d]pyrimidine (CAS 1226071-11-9)
- Insulin Degludec Impurity 17 (CAS CATO-C4X-215717)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com