Pomalidomide Impurity 6 CAS 24666-56-6
| CAS No. | 24666-56-6 |
| Molecular Formula | C5H8N2O2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Pomalidomide Impurity 6 (CAS 24666-56-6, C5H8N2O2HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Pomalidomide Impurity 6 (C5H8N2O2HCl) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 2.0, corresponding to approximately 2 ring(s) or double-bond equivalent(s). With a molecular weight of 164.59 g/mol, it falls into the medium-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H8N2O2 HCl |
| Molecular Weight | 164.59 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1964 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Pomalidomide Standards
- Pomalidomide Impurity 19 (CAS 1001852-10-3)
- Pomalidomide Impurity 1 (CAS 1001852-14-7)
- Pomalidomide Impurity 2 (CAS 1001852-15-8)
- Pomalidomide Related Compound 1 (CAS 1061605-21-7)
- Pomalidomide Impurity 22 (CAS 13139-52-1)
- Pomalidomide Impurity 17 (CAS 1377838-49-7)
- Pomalidomide Impurity 61 (CAS 147291-59-6)
- Pomalidomide M17 (CAS 1547162-41-3)
Recommended Standards
- Amorolfine Impurity 62 (CAS 1800302-57-1)
- Perampanel Impurity 16 (CAS 381233-78-9)
- Benserazide Impurity 32 (CAS 3955-29-1)
- 3-Chloro-6-(2-methyl-1H-imidazol-1-yl)pyridazine (CAS 75792-66-4)
- 6-(Trimethoxysilyl)hexyl methacrylate (CAS 132251-59-3)
- Valganciclovir Hydrochloride EP Impurity L (CAS CATO-C4X-177413)
- 3-(tert-Butoxy)-5-cyclopropoxy-N,N-dimethylpicolinamide (CAS 1243481-03-9)
- 5-Cyclopropyl-3-ethoxypyridine (CAS 1414870-62-4)
- 2-(3-(Naphthalen-1-yl)-6-oxopyridazin-1(6H)-yl)acetic acid (CAS 1269527-71-0)
- Semaglutide impurity 235 (CAS CATO-C4X-2226235)
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