Ledipasvir Impurity 57 CAS CATO-C4X-331357

Description

The occurrence of Ledipasvir Impurity 57 is closely related to a hydroxyl group, an ether linkage, fluorine/chlorine/iodine substitution, a polycyclic aromatic system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

CATO supplies Ledipasvir Impurity 57 (CAS CATO-C4X-331357), a pharmacopoeial impurity reference standard (molecular formula C15H8ClF2IO, MW 404.58 g/mol) used for the identification and quantification of trace impurities in APIs.

The molecular framework of Ledipasvir Impurity 57 (C15H8ClF2IO) is characterized by a hydroxyl group, an ether linkage, fluorine/chlorine/iodine substitution, a polycyclic aromatic system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

As a certified reference material (CRM), Ledipasvir Impurity 57 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

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