Suzetrigine Impurity 16 CAS CATO-C4X-336916
| CAS No. | CATO-C4X-336916 |
| Molecular Formula | C22H21F5N2O5 |
| Molecular Weight | 488.40 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 488.40 g/mol gives Suzetrigine Impurity 16 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Suzetrigine Impurity 16 (CAS CATO-C4X-336916, C22H21F5N2O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Suzetrigine Impurity 16 (C22H21F5N2O5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H21F5N2O5 |
| Molecular Weight | 488.40 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Suzetrigine Standards
- Suzetrigine Impurity 15 (CAS CATO-C4X-336915)
- Suzetrigine Impurity 22 (CAS CATO-C4X-336922)
- Suzetrigine Impurity 31 (CAS CATO-C4X-336931)
- Suzetrigine-d3 (CAS CATO-C4X-336940)
- Suzetrigine Impurity 23 (CAS CATO-C4X-336923)
- Suzetrigine Impurity 26 (CAS CATO-C4X-336926)
- Suzetrigine Impurity 27 (CAS CATO-C4X-336927)
- Suzetrigine Impurity 32 (CAS CATO-C4X-336932)
Recommended Standards
- Lifitegrast Impurity 37 (CAS 1194550-56-5)
- {1-methyl-3-phenyl-5-[3-(trifluoromethyl)phenoxy]-1H-pyrazol-4-yl}methyl 2,6-difluorobenzoate (CAS 318289-46-2)
- Nicergoline-13C-d3 (CAS CATO-C4X-208513)
- 7-((5-(2-(1H-1,2,4-triazol-1-yl)propan-2-yl)-4-methyl-4H-1,2,4-triazol-3-yl)thio)-2,4-bis(trifluoromethyl)-1,8-naphthyridine (CAS 339009-60-8)
- Acarbose EP Impurity D (CAS 68128-53-0)
- Ascorbic Acid EP Impurity G (CAS 66757-69-5)
- Thiamine EP Impurity B HBr (CAS CATO-C4X-187313)
- N-(Acenaphtho[1,2-d]thiazol-8-yl)acetamide (CAS 536728-99-1)
- 2-Amino-5-[(dimethylamino)methyl]pyridine (CAS 1197404-30-0)
- 2',4',6'-Trimethyl-[1,1'-biphenyl]-4-carbaldehyde (CAS 106359-72-2)
- (2R,3R)-2,3-Bis(4-chlorophenyl)butane-2,3-diamine (CAS 2234320-76-2)
- Ethyl 4-bromo-6,7-dimethoxyquinoline-3-carboxylate (CAS 1378260-93-5)
- 2-[(4-Chlorophenyl)sulfanyl]-5-[3-(trifluoromethyl)phenyl]pyridine-3-carbonitrile (CAS 338964-75-3)
- Tau Peptide (45-73) (Exon 2/Insert 1 Domain) trifluoroacetate salt (CAS 2022956-54-1)
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