Modafinil impurity 3 CAS 101094-05-7
| CAS No. | 101094-05-7 |
| Molecular Formula | C15H14O4S |
| Molecular Weight | 290.33 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 290.33 g/mol gives Modafinil impurity 3 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Modafinil impurity 3 (CAS 101094-05-7, C15H14O4S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Modafinil impurity 3 (C15H14O4S) contains a flavonoid core, a sulfone group, a hydroxyl group, an ether linkage. Its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H14O4S |
| Molecular Weight | 290.33 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Sulfur Atoms | 1 |
Related Modafinil Standards
- (R)-Modafinil EP Impurity C (CAS 713134-72-6)
- (S)-Modafinil EP Impurity C (CAS 865811-65-0)
- Modafinil EP Impurity B-d5 (CAS 1329496-95-8)
- Modafinil-d10 Carboxylate (CAS 1246819-82-8)
- Modafinil impurity 8 (CAS 827604-01-3)
- Modafinil impurity 9 (CAS CATO-C4X-17039)
- Modafinil EP Impurity A (CAS 63547-24-0)
- (R)-Modafinil EP Impurity A (CAS 112111-45-2)
Recommended Standards
- Tert-butyl 9-fluoro-3,4-dihydro-[1,4]diazepino[6,7,1-hi]indole-2(1H)-carboxylate (CAS 603300-92-1)
- 4-((4-(Allyloxy)phenyl)sulfonyl)phenol (CAS 97042-18-7)
- tert-Butyl 8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate (CAS 870471-42-4)
- 1-Ethyl-6-[(furan-2-yl)methyl]-3-methyl-5-sulfanylidene-1H,4H,5H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one (CAS 1031967-79-9)
- Febantel Impurity 6 (CAS CATO-C4X-29065)
- rac-Atomoxetine EP Impurity C (CAS 56161-78-5)
- Nabumetone Impurity 7 (CAS 56894-99-6)
- Methyl Ethanesulfonate (CAS 1912-28-3)
- Methicillin Sodium Monohydrate (CAS 7246-14-2)
- 2-(2-methylbutanoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (CAS 1104734-29-3)
- 4-Chloro-5,6,7-trimethoxyquinazoline (CAS 55496-54-3)
- (2Z)-2-(2H-1,3-Benzodioxol-5-yl)-3-{4-[(4-chlorophenyl)sulfanyl]-3-nitrophenyl}prop-2-enenitrile (CAS 866019-60-5)
- 2-(2-Fluoro-4-nitrophenyl)acetonitrile (CAS 853910-00-6)
- Tyr-Proinsulin C-Peptide (55-89) (human) (CAS 139532-11-9)
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