Modafinil impurity 8 CAS 827604-01-3
| CAS No. | 827604-01-3 |
| Molecular Formula | C17H18O3S |
| Molecular Weight | 302.39 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Modafinil impurity 8 (CAS 827604-01-3, C17H18O3S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Modafinil impurity 8 (C17H18O3S) contains a steroid core, a sulfone group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 302.39 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a certified reference material (CRM), Modafinil impurity 8 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C17H18O3S |
| Molecular Weight | 302.39 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Sulfur Atoms | 1 |
Related Modafinil Standards
- Modafinil impurity 9 (CAS CATO-C4X-17039)
- Modafinil EP Impurity B-d5 (CAS 1329496-95-8)
- Modafinil impurity 3 (CAS 101094-05-7)
- (R)-Modafinil EP Impurity C (CAS 713134-72-6)
- (S)-Modafinil EP Impurity C (CAS 865811-65-0)
- Modafinil-d10 Carboxylate (CAS 1246819-82-8)
- Modafinil EP Impurity A (CAS 63547-24-0)
- (R)-Modafinil EP Impurity A (CAS 112111-45-2)
Recommended Standards
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- Teneligliptin impurity 23 (CAS 401564-34-9)
- Flurbiprofen impurity 103 (CAS CATO-C4X-1444103)
- Indobufen Impurity 54 (CAS CATO-C4X-179254)
- Natamycin Impurity 13 (CAS CATO-C4X-204013)
- 3-Chloro-2-ethoxypyridin-4-ol (CAS 2056110-43-9)
- Diclofenac acid Impurity 59 (CAS 304884-75-1)
- n-Cyclopropylpyridine-3-sulfonamide (CAS 1000933-61-8)
- (Di-tert-butylcarbonyloxyiodo)benzol 2,2-Dimethylpropanoic acid, phenyliodine complex 57357-20-7 Bis(2,2-dimethylpropanoato-O)phenyliodide Bis(tert-butylcarbonyloxy)iodobenzene Di-(Pivaloyloxy)iodobenzene (CAS 57357-20-7)
- 1255147-05-7 3217AD 5-Cyclobutyl-1,3,4-oxadiazol-2-ol C6H8N2O2 (CAS 1255147-05-7)
- 1-(4-Methoxyphenyl)-1-phenylethan-1-aminehydrochloride (CAS 1189717-77-8)
- Semaglutide Impurity 187 (CAS CATO-C4X-2226187)
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