(S)-Modafinil EP Impurity C CAS 865811-65-0
| CAS No. | 865811-65-0 |
| Molecular Formula | C16H16O3S |
| Molecular Weight | 288.36 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, (S)-Modafinil EP Impurity C (CAS 865811-65-0, C16H16O3S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of (S)-Modafinil EP Impurity C (C16H16O3S) is characterized by a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, a polycyclic aromatic system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), (S)-Modafinil EP Impurity C meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H16O3S |
| Molecular Weight | 288.36 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Sulfur Atoms | 1 |
Related S Standards
- (R)-Modafinil EP Impurity C (CAS 713134-72-6)
- Modafinil impurity 3 (CAS 101094-05-7)
- Modafinil-d10 Carboxylate (CAS 1246819-82-8)
- Modafinil EP Impurity B-d5 (CAS 1329496-95-8)
- Modafinil impurity 8 (CAS 827604-01-3)
- Modafinil EP Impurity A (CAS 63547-24-0)
- (R)-Modafinil EP Impurity A (CAS 112111-45-2)
- Modafinil (CAS 68693-11-8)
Recommended Standards
- N-((1-(4-Fluorophenyl)-1H-pyrazol-4-yl)methyl)-N-methylpiperidin-4-amine (CAS 2200460-06-4)
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- N-(2-methoxy-5-methylphenyl)-2-(pyridin-2-ylthio)acetamide (CAS 329078-87-7)
- Ethyl 2-[(5-phenylpyrimidin-2-yl)sulfanyl]propanoate (CAS 344282-06-0)
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- Tizanidine impurity 34 (CAS CATO-C4X-144534)
- Carglumic Acid impurity 10 (CAS 862672-48-8)
- 2-(1-(Tert-butoxycarbonyl)azetidin-3-yl)malonic acid (CAS 183062-97-7)
- 5-Bromo-2-fluoro-3-hydroxypyridine (CAS 1012084-53-5)
- 2-(1,3-Thiazol-4-ylmethoxy)phenol (CAS 1094247-98-9)
- 1086378-89-3 4-[(2-Chloropyrimidin-4-yl)oxy]benzaldehyde (CAS 1086378-89-3)
- Progesterone Impurity 78 (CAS CATO-C4X-150278)
- 1-(2,2-Difluoroethyl)piperidine-4-carboxylic acid (CAS 937602-78-3)
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