Methyl 3-cyclopropyl-1-(4-fluorophenyl)-6-(thiophen-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate CAS 1011398-16-5
| CAS No. | 1011398-16-5 |
| Molecular Formula | C21H16FN3O2S |
| Molecular Weight | 393.43 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Methyl 3-cyclopropyl-1-(4-fluorophenyl)-6-(thiophen-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate (C21H16FN3O2S) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Methyl 3-cyclopropyl-1-(4-fluorophenyl)-6-(thiophen-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate (CAS 1011398-16-5) is a high-purity analytical reference standard with the molecular formula C21H16FN3O2S and a molecular weight of 393.43 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Methyl 3-cyclopropyl-1-(4-fluorophenyl)-6-(thiophen-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H16FN3O2S |
| Molecular Weight | 393.43 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Methyl Standards
- 5-(N-Cyclopropyl-N-(furan-2-ylmethyl)sulfamoyl)-N-(thiazol-2-yl)furan-2-carboxamide (CAS 1172704-71-0)
- Ethyl 2-(3-cyclopropyl-6-(1-methyl-1H-pyrazol-3-yl)-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetate (CAS 1173047-60-3)
- 3-(3-(5-Cyclopropyl-3-(trifluoromethyl)-1h-pyrazol-1-yl)propyl)-2-thioxo-2,3-dihydroquinazolin-4(1h)-one (CAS 1006345-64-7)
- 6-Cyclopropyl-2-((2-(3-methoxyphenyl)-2-oxoethyl)thio)-4-(trifluoromethyl)nicotinonitrile (CAS 625377-48-2)
- 6-Cyclopropyl-2-{[2-(4-methoxyphenyl)-2-oxoethyl]sulfanyl}-4-(trifluoromethyl)pyridine-3-carbonitrile (CAS 625377-47-1)
- Ethyl 2-(3-cyclopropyl-6-(thiophen-2-yl)-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetate (CAS 1018051-77-8)
- 2-(3-Cyclopropyl-6-(5-ethylthiophen-2-yl)-4-(trifluoromethyl)-1h-pyrazolo[3,4-b]pyridin-1-yl)acetic acid (CAS 937606-22-9)
- 1-Cyclopropyl-7-(3-((ethylamino)methyl)pyrrolidin-1-yl)-6,8-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (CAS 99734-97-1)
Recommended Standards
- Tegoprazan D6 (CAS CATO-C4X-229761)
- N-[(4-Fluorophenyl)methyl]-2-{4-oxo-7-phenyl-3H,4H-thieno[3,2-d]pyrimidin-3-yl}acetamide (CAS 1105206-96-9)
- Baricitinib Impurity 137 (CAS CATO-C4X-2260137)
- N-(5-fluoro-2-methylphenyl)-2-(4-oxo-7-phenylthieno[3,2-d]pyrimidin-3(4H)-yl)acetamide (CAS 1105223-59-3)
- 3-(2-Bromoethoxy)pyridine (CAS 162541-27-7)
- 4-(4-Methylthiophenyl)phenylboronic acid (CAS 501944-48-5)
- N-(5-(2-(Methylthio)benzoyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)furan-2-carboxamide (CAS 1396851-09-4)
- (1R,2S)-2-methoxycyclopropanamine (CAS 2306254-32-8)
- 5-Bromo-1-(2-chlorobenzyl)-1H-pyrazole (CAS 1427011-39-9)
- (2E)-2-Cyano-3-(2,4-dimethoxyphenyl)-N-(pyridin-2-yl)prop-2-enamide (CAS 1327169-48-1)
- Hemimellitic Acid (CAS 569-51-7)
- Ac-Ala-Ser-Thr-Asp-AMC (I-1785.0005) (CAS 354151-60-3)
- 2-((5-Methylpyridin-2-yl)amino)thiazole-4-carboxylic acid (CAS 1176665-06-7)
- Semaglutide impurity 95 (CAS CATO-C4X-222695)
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