Minocycline Impurity N1 CAS 10118-89-5
| CAS No. | 10118-89-5 |
| Molecular Formula | C23H27N3O7 |
| Molecular Weight | 457.48 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Minocycline Impurity N1.
As a process- or degradation-related impurity, Minocycline Impurity N1 (CAS 10118-89-5, C23H27N3O7) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Minocycline Impurity N1 (C23H27N3O7) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Minocycline Impurity N1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H27N3O7 |
| Molecular Weight | 457.48 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1959 |
| Nitrogen Atoms | 3 |
Related Minocycline Standards
- Minocycline EP Impurity A (HCl salt) (CAS 179471-96-6)
- Minocycline Amino Ethyl Derivative (CAS 4756-93-8)
- Minocycline Impurity (CAS 27179-27-7)
- Minocycline EP Impurity A (CAS 43168-51-0)
- Minocycline (CAS 10118-90-8)
- Minocycline Impurity 70 (CAS CATO-C4X-169970)
- Minocycline EP Impurity E (CAS 864073-42-7)
- Minocycline Impurity 14 (CAS CATO-C4X-169914)
Recommended Standards
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- Alprostadil (Prostaglandin E1) EP Impurity A (CAS 14152-28-4)
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- Methyl 2-amino-1h-indole-3-carboxylate (CAS 113772-14-8)
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