Minocycline EP Impurity A CAS 43168-51-0
| CAS No. | 43168-51-0 |
| Molecular Formula | C23H27N3O7 |
| Molecular Weight | 457.48 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Minocycline EP Impurity A (CAS 43168-51-0) is a certified pharmaceutical impurity reference standard with the molecular formula C23H27N3O7 and a molecular weight of 457.48 g/mol.
Structurally, Minocycline EP Impurity A (C23H27N3O7) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 457.48 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C23H27N3O7 |
| Molecular Weight | 457.48 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1969 |
| Nitrogen Atoms | 3 |
Related Minocycline Standards
- Minocycline Impurity N1 (CAS 10118-89-5)
- Minocycline EP Impurity A (HCl salt) (CAS 179471-96-6)
- Minocycline Amino Ethyl Derivative (CAS 4756-93-8)
- Minocycline Impurity (CAS 27179-27-7)
- Minocycline (CAS 10118-90-8)
- Minocycline Impurity 70 (CAS CATO-C4X-169970)
- Minocycline EP Impurity E (CAS 864073-42-7)
- Minocycline Impurity 14 (CAS CATO-C4X-169914)
Recommended Standards
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- Levosimendan Impurity 7 (CAS 134678-47-0)
- Palbociclib Impurity 11 (CAS CATO-C4X-112511)
- 799268-54-5 18:1 PI(3,4)P2 (CAS 799268-54-5)
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- 2-(4-Fluorophenyl)thiomorpholine (CAS 1001940-38-0)
- 2-Cyano-N-(4-(diethylamino)phenyl)acetamide (CAS 29395-19-5)
- Methyl 8-hydroxy-2,3-dihydrobenzo[b][1,4]dioxine-6-carboxylate (CAS 917836-07-8)
- 2,2,2-Trifluoro-N-((3-methylazetidin-3-yl)methyl)acetamide hydrochloride (CAS 133891-75-5)
- Semaglutide impurity 286 (CAS CATO-C4X-2226286)
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