Lisinopril EP Impurity A CAS 1012-05-1
| CAS No. | 1012-05-1 |
| Molecular Formula | C10H13NO2 |
| Molecular Weight | 179.22 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Lisinopril EP Impurity A (C10H13NO2) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. Its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Lisinopril EP Impurity A (CAS 1012-05-1, C10H13NO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H13NO2 |
| Molecular Weight | 179.22 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 1 |
Related Lisinopril Standards
- Lisinopril EP Impurity A (CAS 5472-95-7)
- Lisinopril Impurity 12 (CAS CATO-C4X-168112)
- Lisinopril Impurity 28 (CAS 1207346-27-7)
- Lisinopril EP Impurity H (CAS 138247-43-5)
- Lisinopril impurity 29 (CAS 1496563-44-0)
- Lisinopril Impurity 11 (CAS CATO-C4X-168111)
- (S)-Lisinopril-d5 Sodium (CAS 1356847-28-3)
- Lisinopril Dihydrate (CAS 83915-83-7)
Recommended Standards
- Lidocaine Impurity 34 (CAS 29183-14-0)
- Indobufen Impurity 32 (CAS 21762-24-3)
- Phenylephrine Impurity 35 (CAS 57236-57-4)
- Indobufen Impurity 33 (CAS 937671-41-5)
- Carbazochrome impurity 45 (CAS CATO-C4X-229145)
- Meropenem Impurity 11 (CAS CATO-C4X-130911)
- Roxatidine Impurity 38 (CAS CATO-C4X-121338)
- 3-(Cyclopentyloxy)isoxazole-5-carboxylic acid (CAS 1707602-92-3)
- (S)-2-methoxy-1-(o-tolyl)ethan-1-amine (CAS 1270048-69-5)
- 3-Iodo-6-methoxyquinoline (CAS 1260743-73-4)
- Benzyl 3-amino-5-fluoropiperidine-1-carboxylate (CAS 1356342-83-0)
- Methyl 3-bromo-2,4,6-trimethylbenzoate (CAS 26584-20-3)
- 4-Methyl-8-quinoxalinesulfonyl Chloride (CAS 13982-84-8)
- Insulin B (22-25) (CAS 34367-73-2)
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