2-(Difluoromethoxy)-4-fluorobenzyl bromide CAS 1017779-42-8
| CAS No. | 1017779-42-8 |
| Molecular Formula | C8H6BrF3O |
| Molecular Weight | 255.03 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
2-(Difluoromethoxy)-4-fluorobenzyl bromide (CAS 1017779-42-8), molecular formula C8H6BrF3O and molecular weight 255.03 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-(Difluoromethoxy)-4-fluorobenzyl bromide (C8H6BrF3O) is characterized by a hydroxyl group, an ether linkage, fluorine/bromine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C8H6BrF3O |
| Molecular Weight | 255.03 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F/Br-containing |
Related Difluoromethoxy Standards
- 5-(Difluoromethoxy)-3-fluorobenzyl bromide (CAS 1017779-39-3)
- 4-(Difluoromethoxy)-3-Fluorobenzyl bromide (CAS 181806-49-5)
- n-(3-(Difluoromethoxy)phenyl)-2,2,2-trifluoroacetamide (CAS 647821-10-1)
- 3-(4-(Difluoromethoxy)phenyl)isoxazole-5-carboxylic acid (CAS 1038311-61-3)
- Ethyl 5-(difluoromethoxy)-1H-indole-3-carboxylate (CAS 1352397-09-1)
- 1-(3-(4-(Difluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)ethanamine (CAS 1707584-74-4)
- 1-(3-(2-(Difluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)ethanamine (CAS 1708250-74-1)
- 2-(3-(3-(Difluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)ethanamine (CAS 1779133-47-9)
Recommended Standards
- 1-Bromo-4-(2,2,2-trifluoroethoxy)benzene (CAS 106854-77-7)
- 2-(Bromomethyl)-4-(difluoromethoxy)-1-fluorobenzene (CAS 1017779-36-0)
- (2-Bromo-3-(trifluoromethyl)phenyl)methanol (CAS 1214330-94-5)
- 1-(Bromomethyl)-4-(difluoromethoxy)-2-fluorobenzene (CAS 1017779-33-7)
- 5-(4-Ethylphenyl)-3-hydrazinyl-1,2,4-triazine (CAS 915924-89-9)
- 3-(4-Isopropylphenyl)piperazin-2-one (CAS 1246548-99-1)
- 4-Chloro-2,3-dimethyl-6-(trifluoromethyl)quinoline (CAS 1713463-07-0)
- (2-Bromoethyl)benzene-d5 (CAS 35845-64-8)
- 1-(Spiro[4.5]dec-7-en-7-yl)pent-4-en-1-one (CAS 224031-70-3)
- tert-Butyl 6-chloro-3H-spiro[benzofuran-2,4'-piperidine]-1'-carboxylate (CAS 2626989-34-0)
- 3-(3-(2-(1-(1-Methylpiperidin-4-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl)pentanenitrile (CAS 1956336-08-5)
- Corytuberine (CAS 517-56-6)
- 2-Isopropoxy-4-methylphenylboronic acid (CAS 221111-03-1)
- Semaglutide impurity 65 (CAS CATO-C4X-222665)
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