Palonosetron USP Related Compound B CAS 1021456-82-5
| CAS No. | 1021456-82-5 |
| Molecular Formula | C19H22N2O2 |
| Molecular Weight | 310.39 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Palonosetron USP Related Compound B.
As a process- or degradation-related impurity, Palonosetron USP Related Compound B (CAS 1021456-82-5, C19H22N2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C19H22N2O2, Palonosetron USP Related Compound B contains a steroid core, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 310.39 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Palonosetron USP Related Compound B meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H22N2O2 |
| Molecular Weight | 310.39 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Nitrogen Atoms | 2 |
Related Palonosetron Standards
- Palonosetron USP Related Compound A (CAS 813425-83-1)
- Palonosetron Impurity 9 (CAS 2446343-19-5)
- Palonosetron (6S)-Hydroxy (S,S)-Isomer (CAS 848074-08-8)
- Palonosetron Impurity 34 (CAS 1227162-74-4)
- Palonosetron Impurity 35 (CAS CATO-C4X-110535)
- Palonosetron Impurity 13 (CAS 2216753-67-0)
- Palonosetron Impurity 14 (CAS 177932-92-2)
- Palonosetron Impurity 15 (CAS 135729-78-1)
Recommended Standards
- Entecavir Impurity 25 (CAS 110567-22-1)
- Netupitant Impurity 41 (CAS CATO-C4X-122341)
- 1-([1,1'-biphenyl]-2-yl(phenyl)methyl)-1H-imidazole (CAS CATO-C3D-6176)
- Netupitant Impurity 42 (CAS CATO-C4X-122342)
- Ulipristal Impurity 6 (CAS 1655514-74-1)
- Everolimus Impurity 38 (CAS CATO-C4X-112238)
- Famotidine EP Impurity E (CAS 129083-44-9)
- 7-Fluoro-6-nitro-4-(prop-2-yn-1-yl)-2H-benzo[b][1,4]oxazin-3(4H)-one (CAS 103361-40-6)
- 2-(2-(3-Cyclohexylureido)thiazol-4-yl)-N-phenylacetamide (CAS 921487-92-5)
- 5-{[(Butan-2-yl)amino]methyl}-2-methoxyphenol (CAS 1019599-59-7)
- 1-Bromo-2,3,4-trimethoxybenzene (CAS 10385-36-1)
- 3-((4-Nitrophenoxy)methyl)pyridine (CAS 85002-83-1)
- (5-(2-Aminopyridin-3-yl)isoxazol-3-yl)methanol (CAS 1166997-13-2)
- Peptide Impurity 27 (CAS 1350456-68-6)
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