Palonosetron Impurity 9 CAS 2446343-19-5
| CAS No. | 2446343-19-5 |
| Molecular Formula | C19H24N2O2 |
| Molecular Weight | 312.41 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 312.41 g/mol gives Palonosetron Impurity 9 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Palonosetron Impurity 9 (CAS 2446343-19-5) is a certified pharmaceutical impurity reference standard with the molecular formula C19H24N2O2 and a molecular weight of 312.41 g/mol.
Palonosetron Impurity 9 (C19H24N2O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H24N2O2 |
| Molecular Weight | 312.41 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Nitrogen Atoms | 2 |
Related Palonosetron Standards
- Palonosetron USP Related Compound A (CAS 813425-83-1)
- Palonosetron (6S)-Hydroxy (S,S)-Isomer (CAS 848074-08-8)
- Palonosetron USP Related Compound B (CAS 1021456-82-5)
- Palonosetron Impurity 34 (CAS 1227162-74-4)
- Palonosetron Impurity 35 (CAS CATO-C4X-110535)
- Palonosetron Impurity 13 (CAS 2216753-67-0)
- Palonosetron Impurity 14 (CAS 177932-92-2)
- Palonosetron Impurity 15 (CAS 135729-78-1)
Recommended Standards
- Palbociclib Impurity 81 (CAS CATO-C4X-112581)
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- Netupitant Impurity 3 (CAS CATO-C4X-12233)
- tert-Butyl 4-(naphthalen-1-yl)piperazine-1-carboxylate (CAS 206347-34-4)
- Lodoxamide lmpurity 14 (CAS 67451-25-6)
- Clindamycin Impurity 98 (CAS 68225-59-2)
- Valaciclovir Impurity 57 (CAS CATO-C4X-124857)
- N-(5-Amino-2-methylphenyl)-2-(2-methylphenoxy)-acetamide (CAS 953753-87-2)
- 3-([1,1'-Biphenyl]-4-yl(phenyl)phosphino)benzoic acid (CAS 62350-80-5)
- Deferasirox Impurity 26 (CAS 1688656-83-8)
- Tadalafil Impurity N23 (CAS 951661-84-0)
- 2-Azetidinomethyl-2-chlorobenzophenone (CAS 898755-03-8)
- 5,10,15-Trihexyl-10,15-dihydro-5H-diindolo[3,2-a:3',2'-c]carbazole (CAS 1020085-72-6)
- Semaglutide (CAS CATO-C4X-2226105)
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