Ezetimibe Impurity 78 CAS CATO-C4X-109878
| CAS No. | CATO-C4X-109878 |
| Molecular Formula | C30H39F2NO4Si2 |
| Molecular Weight | 571.80 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 571.80 g/mol gives Ezetimibe Impurity 78 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Ezetimibe Impurity 78 (CAS CATO-C4X-109878) is a certified pharmaceutical impurity reference standard with the molecular formula C30H39F2NO4Si2 and a molecular weight of 571.80 g/mol.
The molecular framework of Ezetimibe Impurity 78 (C30H39F2NO4Si2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Ezetimibe Impurity 78 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C30H39F2NO4Si2 |
| Molecular Weight | 571.80 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Ezetimibe Standards
- Ezetimibe Impurity 120 (CAS 1197343-09-1)
- Ezetimibe Impurtiy N5 (CAS 1621715-63-6)
- Ezetimibe Impurity 105 (CAS 1296129-16-2)
- Ezetimibe Impurity 107 (CAS 2363086-22-8)
- Ezetimibe Impurity N13 (CAS 1185883-40-2)
- Ezetimibe Impurity 40 (CAS 190448-57-8)
- Ezetimibe Hydroxy Glucuronide (CAS 536709-33-8)
- Ezetimibe Phenoxy Glucuronide-d4 (CAS 1426174-41-5)
Recommended Standards
- (E)-7-[5-[[[(1,1-Dimethylethyl)dimethylsilyl]oxy]methyl]-4-(4-fluorophenyl)-2,6-bis(1-methylethyl)-3-pyridinyl]-5-hydroxy-3-oxo-6-heptenoic Acid Methyl Ester 124863-85-0 Methyl rac-(E)-7-[5-tert-Butyldimethylsilyloxymethyl-2,6-diisopropyl-4-(4-fluorophenyl)-3-pyridinyl]-5-hydroxy-3-oxo-6-heptenoate (CAS 124863-85-0)
- 3-[2-(2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}ethyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]-1-[3-(trifluoromethyl)phenyl]urea (CAS 339101-74-5)
- m-dPEG<SUP>®</SUP><SUB>8</SUB>-Lipoamide (CAS 1334172-67-6)
- (S)-(+)-(3,5-Dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)bis[(1S)-1-phenylethyl]amine 380230-02-4 (+)-N,N-BIS[(1S)-1-PHENYLETHYL]-DINAPHTHO[2,1-D:1',2'-F][1,3,2]DIOXAPHOSPHEPIN-4-AMINE, (11BR);(S)-(+)-(3,5-DIOXA-4-PHOSPHA-CYCLOHEPTA[2,1-A3,4-A']DINAPHTHALEN-4-YL)BIS[(1S)-1-PHENYLETHYL]AMINE;(S)-(+)-(3,5-DIOXA-4-PHOSPHA-CYCLOHEPTA[2,1-A:3,4-A']DINAPHTHALEN-4-YL)BIS[(1S)-1-PHENYLETHYL]AMINE;(S,S,S)-(+)-(3,5-DIOXA-4-PHOSPHACYCLOHEPTA[2,1-A:3,4-A']DINAPHTHALEN-4-YL)BIS(1-PHENYLETHYL)AMINE;(S)-(+)-(3,5-Dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)bis[(1S)-1-phenylethyl]amine SC11364 (CAS 380230-02-4)
- Folic Acid Impurity 22 (CAS 921-03-9)
- Sacubitril impurity 50 (CAS 1039307-95-3（free base）)
- Anagrelide Impurity 21 (CAS 17700-09-3)
- 1-(Indolizin-1-yl)ethanone (CAS 128353-08-2)
- N-(2-Isopropylphenyl)-2-nitrobenzenesulfonamide (CAS 350993-24-7)
- 4-(Isobutyrylamino)benzoic acid (CAS 28547-07-1)
- 2-(Pyrrolidin-2-yl)-1H-indole (CAS 112565-42-1)
- 2-Iodo-5-methoxypyrazine (CAS 942624-06-8)
- n-(4-Chloro-3-fluorobenzyl)-1-cyclopropylmethanamine (CAS 1250638-08-4)
- Semaglutide Impurity 129 (CAS 2490269-79-7)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com