Metronidazole Impurity 29 CAS 102274-40-8
| CAS No. | 102274-40-8 |
| Molecular Formula | C13H12ClN3O4 |
| Molecular Weight | 309.71 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Metronidazole Impurity 29 (C13H12ClN3O4) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Metronidazole Impurity 29 (CAS 102274-40-8, C13H12ClN3O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H12ClN3O4 |
| Molecular Weight | 309.71 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Metronidazole Standards
- Metronidazole Impurity 28 (CAS 102274-41-9)
- Metronidazole Impurity 30 (CAS 13182-90-6)
- Metronidazole Impurity 27 (CAS CATO-C4X-140527)
- Metronidazole Impurity 9 (CAS 87009-72-1)
- Metronidazole benzoate (CAS 13182-89-3)
- Metronidazole beta-D-Glucuronide (CAS 100495-98-5)
- Metronidazole Impurity 25 (CAS 16156-93-7)
- Metronidazole Impurity 20 (CAS 19765-12-9)
Recommended Standards
- Avanafil Impurity 42 (CAS CATO-C4X-111842)
- Resmetirom impurity 93 (CAS CATO-C4X-291293)
- Dimethyl 1-(3-chloro-2-methylphenyl)-1H-1,2,3-triazole-4,5-dicarboxylate (CAS 895650-44-9)
- 5-[(4-chlorophenyl)sulfanyl]-2-nitrobenzoic acid (CAS 1036467-51-2)
- Irbesartan Impurity 9 (CAS 1213252-83-5)
- Cefaclor Impurity 61 (CAS CATO-C4X-127061)
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- (Cys2)-Neuropeptide Y-8-aminooctanoyl-(D-Cys27)-Neuropeptide Y (25-32) (H-3298.0500) (CAS 128806-04-2)
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