Metronidazole Impurity 28 CAS 102274-41-9
| CAS No. | 102274-41-9 |
| Molecular Formula | C13H12ClN3O4 |
| Molecular Weight | 309.71 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Metronidazole Impurity 28 (CAS 102274-41-9) is a certified pharmaceutical impurity reference standard with the molecular formula C13H12ClN3O4 and a molecular weight of 309.71 g/mol.
Based on its molecular formula C13H12ClN3O4, Metronidazole Impurity 28 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 309.71 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H12ClN3O4 |
| Molecular Weight | 309.71 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Metronidazole Standards
- Metronidazole Impurity 29 (CAS 102274-40-8)
- Metronidazole Impurity 30 (CAS 13182-90-6)
- Metronidazole Impurity 27 (CAS CATO-C4X-140527)
- Metronidazole Impurity 9 (CAS 87009-72-1)
- Metronidazole benzoate (CAS 13182-89-3)
- Metronidazole beta-D-Glucuronide (CAS 100495-98-5)
- Metronidazole Impurity 25 (CAS 16156-93-7)
- Metronidazole Impurity 20 (CAS 19765-12-9)
Recommended Standards
- Avanafil Impurity 42 (CAS CATO-C4X-111842)
- Dimethyl 1-(3-chloro-2-methylphenyl)-1H-1,2,3-triazole-4,5-dicarboxylate (CAS 895650-44-9)
- 5-(Chloromethyl)-2-(3-fluoro-4-(trifluoromethyl)phenyl)-4-methylthiazole (CAS 317319-33-8)
- Resmetirom impurity 93 (CAS CATO-C4X-291293)
- Papaverine EP Impurity C HCl (3,4-Dihydropapaverine HCl) (CAS 5884-22-0)
- Idebenone Impurity 4 (CAS 58186-01-9)
- Nicorandil Impurity 46 3Nitrate (CAS CATO-C4X-190746)
- (1-Phenylpiperidin-3-yl)methanol (CAS 1081515-81-2)
- Arachidonyl-2-chloroethylamide (CAS 220556-69-4)
- 5-(propan-2-yl)-1,3-thiazole-2-carbaldehyde (CAS 1461714-41-9)
- Methyl 3-(5-methoxythiophen-2-yl)propanoate (CAS 1000896-80-9)
- 2-(Acetoxymethyl)-6-(phenylthio)tetrahydro-2H-pyran-3,4,5-triyl triacetate (CAS 13992-16-0)
- N-(2-((4-(4-Fluorophenyl)piperazin-1-yl)sulfonyl)ethyl)propionamide (CAS 897618-38-1)
- 3X Flag Peptide trifluoroacetate salt (CAS 402750-12-3)
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