3-Chloro-N-(4-(trifluoromethoxy)phenyl)naphtho[1,2-b]thiophene-2-carboxamide CAS 1024164-16-6
| CAS No. | 1024164-16-6 |
| Molecular Formula | C20H11ClF3NO2S |
| Molecular Weight | 421.82 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
3-Chloro-N-(4-(trifluoromethoxy)phenyl)naphtho[1,2-b]thiophene-2-carboxamide (CAS 1024164-16-6) is a high-purity analytical reference standard with the molecular formula C20H11ClF3NO2S and a molecular weight of 421.82 g/mol.
The molecular framework of 3-Chloro-N-(4-(trifluoromethoxy)phenyl)naphtho[1,2-b]thiophene-2-carboxamide (C20H11ClF3NO2S) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H11ClF3NO2S |
| Molecular Weight | 421.82 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Chloro Standards
- 2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-sulfamoylphenethyl)acetamide (CAS 478063-71-7)
- 3-Chloro-2-{[7-(4-methylphenyl)-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl]sulfanyl}-5-(trifluoromethyl)pyridine (CAS 338775-16-9)
- N-(2-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)thio)-1-methyl-1H-imidazol-5-yl)morpholine-4-carboxamide (CAS 303151-94-2)
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- N'-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-4-fluoro-N'-methyl-N-(prop-2-yn-1-yl)benzenesulfonohydrazide (CAS 338748-66-6)
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Recommended Standards
- N-(2-(3-(4-Chlorophenyl)-6-oxopyridazin-1(6H)-yl)ethyl)-2-(trifluoromethyl)benzamide (CAS 921577-37-9)
- 3-((4-Chlorophenyl)sulfonyl)-2-hydroxy-2-methyl-N-(3-(trifluoromethyl)phenyl)propanamide (CAS 338424-60-5)
- 5-(4-Chlorophenyl)-N-((2-(2,2,2-trifluoroethoxy)pyridin-3-yl)methyl)nicotinamide (CAS 1026822-49-0)
- 3-(4-Chlorobenzenesulfonyl)-2-hydroxy-2-methyl-N-[4-(trifluoromethyl)phenyl]propanamide (CAS 338956-18-6)
- 4-(5-Methyl-3-nitro-1h-pyrazol-1-yl)butanoyl chloride (CAS 1006459-08-0)
- 5-Aminopyridine-2-thiol (CAS 760117-50-8)
- (4R,5S)-4,5-Diphenyl-2-(pyridin-2-yl)-4,5-dihydrooxazole (CAS 1108603-34-4)
- (2s,4r)-4-Fluoropyrrolidine-2-carboxamide hydrochloride (CAS 796884-06-5)
- 5-Fluoro-4-hydroxynicotinonitrile (CAS 1256785-73-5)
- N,N'-(1,3-Phenylene)bis(N-phenylacetamide) (CAS 847996-57-0)
- 1-(3-fluorophenyl)-3-methylpiperazine (CAS 1250098-88-4)
- (4Z)-1-Phenyl-4-({[(pyridin-3-yl)methyl]amino}methylidene)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-one (CAS 477851-35-7)
- Methyl 5-acetyl-4,5-dihydroisoxazole-3-carboxylate (CAS 150174-91-7)
- Semaglutide impurity 208 (CAS CATO-C4X-2226208)
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