4-Chloro-3-[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1h-pyrazol-4-yl)sulfamoyl]benzoic acid CAS 109030-05-9
| CAS No. | 109030-05-9 |
| Molecular Formula | C18H16ClN3O5S |
| Molecular Weight | 421.85 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-Chloro-3-[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1h-pyrazol-4-yl)sulfamoyl]benzoic acid.
4-Chloro-3-[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1h-pyrazol-4-yl)sulfamoyl]benzoic acid (CAS 109030-05-9), molecular formula C18H16ClN3O5S and molecular weight 421.85 g/mol, is a CATO reference standard with documented purity and traceability.
4-Chloro-3-[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1h-pyrazol-4-yl)sulfamoyl]benzoic acid (C18H16ClN3O5S) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-Chloro-3-[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1h-pyrazol-4-yl)sulfamoyl]benzoic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H16ClN3O5S |
| Molecular Weight | 421.85 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Chloro Standards
- 2-Chloro-5-[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)sulfamoyl]benzoic acid (CAS 438031-01-7)
- 4-Chloro-N-(4-(((3-(trifluoromethyl)phenyl)thio)methyl)phenyl)benzamide (CAS 338398-62-2)
- 3-Chloro-2-{[7-(4-methylphenyl)-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl]sulfanyl}-5-(trifluoromethyl)pyridine (CAS 338775-16-9)
- N-(2-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)thio)-1-methyl-1H-imidazol-5-yl)morpholine-4-carboxamide (CAS 303151-94-2)
- N-(2-chloro-5-(5-methylbenzo[d]oxazol-2-yl)phenyl)-3-methyl-4-nitrobenzamide (CAS 301354-47-2)
- 3-Chloro-N-(4-(trifluoromethoxy)phenyl)naphtho[1,2-b]thiophene-2-carboxamide (CAS 1024164-16-6)
- 2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-sulfamoylphenethyl)acetamide (CAS 478063-71-7)
- 1-(4-chloro-2-nitrobenzenesulfonyl)-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine 1025588-81-1 MS-10439 (CAS 1025588-81-1)
Recommended Standards
- 1-(Tert-butyl) 2-ethyl (2S,5S)-5-(2-chloro-5-(trifluoromethyl)phenyl)pyrrolidine-1,2-dicarboxylate (CAS 1648890-05-4)
- Amlodipine Metabolite 4 (CAS 113994-45-9)
- 2-(4-Chlorophenyl)-6-(1-(1,1-dioxidotetrahydrothiophen-3-yl)-1H-pyrazol-5-yl)-4-methyl-1,2,4-triazine-3,5(2H,4H)-dione (CAS 477709-02-7)
- Tegoprazan Impurity 30 (CAS CATO-C4X-229730)
- Sodium 4-benzamido-6-((4-(ethyl(naphthalen-1-yl)carbamoyl)phenyl)diazenyl)-5-hydroxynaphthalene-1,7-disulfonate (CAS 6417-36-3)
- Tomatidine (CAS 77-59-8)
- [(3S)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]phosphonic Acid Hydrobromide (CAS 1246817-25-3)
- 6-Amino-3-fluoro-2-hydroxybenzonitrile (CAS 2090014-06-3)
- Fosfomycin Impurity 82 (CAS 789427-15-2)
- 1356090-88-4 2-Methyl-N-[(1E)-1-(2,4,6-trifluorophenyl)-ethylidene]propane-2-sulfinamide (CAS 1356090-88-4)
- 4-Difluoromethoxy-3-(trifluoromethyl)pyridine (CAS 1803825-89-9)
- 2-(6-Bromo-3-(difluoromethyl)-5-iodopyridin-2-yl)acetonitrile (CAS 1805243-74-6)
- N4-Benzyl-2-(3-methylpiperidin-1-yl)-5-nitropyrimidine-4,6-diamine (CAS 585563-56-0)
- Liraglutide Impurity 17 TFA Salt (CAS CATO-C4X-199217)
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