N-(2-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)thio)-1-methyl-1H-imidazol-5-yl)morpholine-4-carboxamide CAS 303151-94-2
| CAS No. | 303151-94-2 |
| Molecular Formula | C15H15ClF3N5O2S |
| Molecular Weight | 421.83 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including N-(2-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)thio)-1-methyl-1H-imidazol-5-yl)morpholine-4-carboxamide.
N-(2-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)thio)-1-methyl-1H-imidazol-5-yl)morpholine-4-carboxamide (CAS 303151-94-2) is a high-purity analytical reference standard with the molecular formula C15H15ClF3N5O2S and a molecular weight of 421.83 g/mol.
Structurally, N-(2-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)thio)-1-methyl-1H-imidazol-5-yl)morpholine-4-carboxamide (C15H15ClF3N5O2S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 421.83 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H15ClF3N5O2S |
| Molecular Weight | 421.83 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
| Sulfur Atoms | 1 |
Related N Standards
- 3-Chloro-2-{[7-(4-methylphenyl)-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl]sulfanyl}-5-(trifluoromethyl)pyridine (CAS 338775-16-9)
- N-(2-chloro-5-(5-methylbenzo[d]oxazol-2-yl)phenyl)-3-methyl-4-nitrobenzamide (CAS 301354-47-2)
- 3-Chloro-N-(4-(trifluoromethoxy)phenyl)naphtho[1,2-b]thiophene-2-carboxamide (CAS 1024164-16-6)
- 2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-sulfamoylphenethyl)acetamide (CAS 478063-71-7)
- 4-Chloro-3-[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1h-pyrazol-4-yl)sulfamoyl]benzoic acid (CAS 109030-05-9)
- 2-Chloro-5-[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)sulfamoyl]benzoic acid (CAS 438031-01-7)
- N'-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-4-fluoro-N'-methyl-N-(prop-2-yn-1-yl)benzenesulfonohydrazide (CAS 338748-66-6)
- 4-Chloro-N-(4-(((3-(trifluoromethyl)phenyl)thio)methyl)phenyl)benzamide (CAS 338398-62-2)
Recommended Standards
- 2-Amino-4-chloro-N-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]benzamide (CAS 206350-07-4)
- N-(5-(5-chlorobenzo[d]oxazol-2-yl)-2-methylphenyl)-3-methyl-4-nitrobenzamide (CAS 400740-94-5)
- (2R,3R,4S,5R)-2-(6-((5-Chloro-2-methoxybenzyl)amino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol (CAS 34349-36-5)
- Avanafil Impurity 129 (CAS CATO-C4X-1118129)
- 5-Chlorobenzo[b]thiophene-3-carbonitrile (CAS 16296-79-0)
- 207742-88-9 3,4,5-trihydroxybenzaldehyde hydrate 3,4,5-tris(oxidanyl)benzaldehyde hydrate A814872 (CAS 207742-88-9)
- 2-Chloro-6-methyl-N-vinylpyridin-3-amine (CAS 1810069-94-3)
- (1-(Cyclopentylsulfonyl)cyclopropyl)methanol (CAS 1890676-16-0)
- 2-(4-Iodophenyl)-8-methylimidazo[1,2-a]pyridine-3-carbaldehyde (CAS 887360-05-6)
- Ethyl 5-hydroxy-2-methylisonicotinate (CAS 52685-79-7)
- 3-(Methoxymethyl)-3-methylpiperidine (CAS 955082-73-2)
- Ethyl 4-(4-fluorophenyl)-6-hydroxy-2-phenyl-4,5-dihydro-5-pyrimidinecarboxylate (CAS 477867-27-9)
- 2-(3,4-Dimethoxyphenyl)-4-oxo-1,4-dihydroquinoline-8-carboxylic acid (CAS 90034-82-5)
- Semaglutide impurity 65 (CAS CATO-C4X-222665)
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