Anastrozole EP Impurity D CAS 1027160-12-8
| CAS No. | 1027160-12-8 |
| Molecular Formula | C15H16Br2N2 |
| Molecular Weight | 384.11 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Anastrozole EP Impurity D meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Anastrozole EP Impurity D (CAS 1027160-12-8, C15H16Br2N2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Anastrozole EP Impurity D (C15H16Br2N2) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, bromine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C15H16Br2N2 |
| Molecular Weight | 384.11 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 2 |
Related Anastrozole Standards
- Anastrozole Impurity 19 (CAS 918312-71-7)
- Anastrozole Impurity 21 (CAS CATO-C4X-123921)
- Anastrozole Impurity N2 (CAS 1186102-55-5)
- Anastrozole Impurity 37 (CAS CATO-C4X-123937)
- Anastrozole Impurity 27 (CAS CATO-C4X-123927)
- Anastrozole Diacid (CAS 1338800-81-9)
- Anastrozole Impurity 15 (CAS 2469244-33-3)
- Anastrozole Impurity 16 (CAS 120512-04-1)
Recommended Standards
- 2-(Benzyloxy)-1,3-dibromo-5-isopropylbenzene (CAS 2379321-51-2)
- 1-((2R,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)-5-iodopyrimidine-2,4(1H,3H)-dione (CAS 1203461-96-4)
- 3-Hydroxy-2,3-dimethylbutan-2-yl hydrogen (4-(4-bromothiazol-5-yl)phenyl)boronate (CAS 2223050-78-8)
- 2-(2,6-dioxo-3-piperidyl)-4-iodo-isoindoline-1,3-dione (CAS 959150-64-2)
- Ezetimibe Impurity 24 (CAS 528565-93-7)
- Ubrogepant Impurity 3 (CAS CATO-C4X-34023)
- Pramipexole EP Impurity C (CAS 1973461-14-1)
- 4-(4,5-Dimethyl-1h-imidazol-1-yl)-3-methylbenzaldehyde (CAS 1247713-77-4)
- 8-Amino-1,2,3,4-tetrahydroquinoxaline-5-carbonitrile (CAS 573758-53-9)
- 1-Mesitylethane-1-sulfonyl chloride (CAS 1247509-42-7)
- (Z-Cys.OMe)2 (CAS 3693-95-6)
- Palbociclib Impurity 108 (CAS CATO-C4X-1125108)
- Benzyl 3-bromo-2-chloro-6-fluorobenzoate (CAS 2586125-74-6)
- Osteogenic Growth Peptide (CAS 132996-61-3)
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