Escitalopram Impurity 2 CAS 103146-25-4
| CAS No. | 103146-25-4 |
| Molecular Formula | C20H23FN2O2 |
| Molecular Weight | 342.41 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Escitalopram Impurity 2 (CAS 103146-25-4), a pharmacopoeial impurity reference standard (molecular formula C20H23FN2O2, MW 342.41 g/mol) used for the identification and quantification of trace impurities in APIs.
Escitalopram Impurity 2 (C20H23FN2O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C20H23FN2O2 |
| Molecular Weight | 342.41 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Escitalopram Standards
- Escitalopram EP Impurity A(R-Isomer) (CAS CATO-C4X-110920)
- Escitalopram EP Impurity M (CAS 1881237-26-8)
- ESCitalopram N-Oxide (CAS 917482-45-2)
- EsCitalopram EP Impurity H (CAS 63284-72-0)
- EsCitalopram Impurity 3 (CAS CATO-C4X-16343)
- Escitalopram EP Impurity K (CAS 128196-02-1)
- EsCitalopram EP Impurity I (CAS 1370643-22-3)
- Escitalopram EP Impurity G (R-Isomer) (CAS CATO-C4X-110989)
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Why CATO?
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